Deutsches Krebsforschungszentrum

Ruprecht-Karls-Universitat Heidelberg

Rajendra-Prasad Maskey

Michael Boutros

Daniel Gilbert

Florian Fuchs

Sandra Steinbrink

Corinna Koch

Compounds of formula (IIc); wherein Xand Xindependently from each other are N or CRwherein Rmay be same or different; Y, Y, Yand Yindependently from each other are N or CRwherein Rmay be same or different and wherein up to 3 of the group Y, Y, Yand Ymay be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer. 

Chromene derivatives and their analogs as Wnt pathway antagonists

Chromene derivatives and their analoga as Wnt pathway antagonists

The present invention relates to compounds having the general formula (I) with the definitions of X1-X3, Y1, Y2, L1, R1 and R2 given below and/or solvates, hydrates, esters and pharmaceutically acceptable salts thereof. Furthermore, the invention relates to the use of said compounds for modulating of the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer. 

Tricyclic pyrimidine derivatives as wnt antagonists

Growing community of inventors

Heidelberg, Germany

Rajendra-Prasad Maskey