Cadila Healthcare Limited

Rajendra Chopade

Rajesh Bahekar

Gaurav Gupta

Mukul R Jain

Ranjit C Desai

Suresh Giri

Vijay Prajapati

The present invention relates to novel short chain peptides of formula (I) which can be useful as a vaccine when in conjugation with suitable immunogenic carrier and suitable adjuvant. These are useful for the treatment for the PCSK9 mediated diseases.A-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-B&#x2003;&#x2003; Formula (I)

Peptide based PCSK9 vaccine

The present invention relates to novel short-chain peptides of the general formula (I), which are selective and peripherally acting KOR agonist, their tautomeric forms, their enantiomers, their diastereoisomers, their stereoisomers, their pharmaceutically accepted salts, or prodrugs thereof which are useful in the treatment or prevention of diseases in which the Kappa (&#x3ba;) opioid receptors (KOR) are involved, such as treatment or prevention of visceral pain, hyperalgesia, rheumatoid arthritic inflammation, osteoarthritic inflammation, IBD inflammation, IBS inflammation, ocular inflammation, otitic inflammation or autoimmune inflammation. The invention also relates to process for the manufacture of said short-chain peptides, and pharmaceutical compositions containing them and their use.

Short-chain peptides as Kappa (&#x3ba;) opioid receptors (KOR) agonist

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Gujarat, India

Rajendra Chopade