Nps Allelix Corporation

Allelix Biopharmaceuticals Inc.

Allelix Biopharmaceutical Inc.

Nps Alleix Corp.

Rajender Kamboj

Stephen L Nutt

Candace E Elliott

Michael A Wosnick

Lee Shekter

Robert Foldes

Donald G Munroe

Tejal B Vyas

Ashwani K Gupta

Vikarna Rampersad

Sally-Lin Adams

Diana Peters

Roman Zastawny

Robert Fantaske

Fatemeh Kooshesh

Fatemch Kooshesh

Stephen Nutt

Joshua Owolabi

Described herein are isolated polynucleotides which code for an AMPA-type human CNS receptor, designated the human GluR4B receptor. The receptor is characterized structurally and the construction and use of cell lines expressing the receptor is disclosed.

AMPA-binding human GluR4 receptors

A novel, isolated EDG receptor that upon activation results in increased induction of IL-8 or NF-&#x3ba;B. Preferably, the EDG receptor is a human EDG-4 receptor, which has an amino acid sequence shown in FIGS.A andB, or a variant of these sequences having at least 91% sequence identity.

Isolated human EDG-4 receptor

Described herein are isolated polynucleotides which code for a family of AMPA-type human CNS receptors. The receptors are characterized structurally and the construction and use of cell lines expressing these receptors are disclosed.

AMPA-binding human GluR3 receptors

Neurotransmission by excitatory amino acids (EAAS) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for EAA receptors of one family of human NMDA-binding type receptors has now been isolated and receptor proteins characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

Human CNS receptors of the NMDA-R1 family

Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

Kainate-binding, human CNS receptors of the EAA3 family

Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. This neurotransmission has been found to be modulated by certain modulatory proteins. DNA coding for a family of such modulatory proteins has now been isolated and the modulatory proteins have been characterized. Herein described are recombinant cell lines which produce these modulatory proteins as heterologous membrane-bound products. Also described are related aspects of the invention, which are of commercial significance, including the use of cell lines which express the modulatory proteins either homomerically, or heteromerically in a complex with an NMDA receptor, as a tool for discovery of compounds which affect the function of the modulatory proteins.

Human NR2A binding assay

A lysolipid receptor, a human EDG-4 receptor, a method of identifying lysolipid receptors involved in inflammatory response and the lysolipid receptors so identified, and a method of identifying ligands which interact with such lysolipid receptors.

Isolated human EDG-4 receptor and polynucletide encoding said receptor

Described herein are isolated polynucleotides which code for an AMPA-type human CNS receptor, designated the human GluR2B receptor. The receptor is charactereized structurally and the construction and use of cell lines expressing these receptor is disclosed.

Ampa-binding human GluR2 receptors

AMPA-binding human GLuR3 receptors

Described herein are isolated polynucleotides which code for an AMPA-type human CNS receptor, designated the human GluR1B receptor. The receptor is characterized structurally and the construction and use of cell lines expressing the receptor is disclosed.

AMPA-binding human GluR1 receptors

Ampa-binding human GluR3 receptors

Described herein are isolated polynucleotides which code for an AMPA-type human CNS receptor, designated the human GluR2B receptor. The receptor is characterized structurally and the construction and use of cell lines expressing these receptor is disclosed.

AMPA-binding human GluR2 receptors

Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. This neurotransmission has been found to be modulated by certain modulatory proteins. DNA coding for a family of such modulatory proteins has now been isolated and the modulatory proteins have been characterized. Herein described are recombinant cell lines which produce these modulatory proteins as heterologous membrane-bound products. Also described are related aspects of the invention, which are of commercial significance, including the use of cell lines which express the modulatory proteins either homomerically, or hotoromorically in a complex with an NMDA receptor, as a tool for discovery of compounds which affect the function of the modulatory proteins.

Ionotropic human glutamate receptor subunit NR3

Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

Growing community of inventors

Mississauga, Canada

Rajender Kamboj