Icn Pharmaceuticals, Inc.

Rajanikanth Bandaru

Devron R Averett

Kandasamy Ramasamy

C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments a cyano sugar is converted into thiocarboxamide, and subsequently condensed to form an azole ring. In a second class of preferred embodiments a cyano sugar is condensed with an amino acid to provide the azole ring. In a third class of preferred embodiments a halo sugar is condensed with a preformed heterocycle to provide the azole ring.

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Irvine, CA, United States of America

Rajanikanth Bandaru