Integrated Biotherapeutics, Inc.

Integrated Biotherapeutic Vaccines, Inc.

Abvacc, Inc.

Rajan Prasad Adhikari

Mohammad Javad Aman

Hatice Karauzum

Thomas Kort

Sergey Shulenin

Nils Williston

Kelly Lyn Warfield

Tam Nguyen

Frederick Wayne Holtsberg

Frederick W Holtsberg

Arundhathi Venkatasubramaniam

Jawad Sarwar

Sathya Venkataramani

Shweta Kailasan

Tam Luong Nguyen

The present disclosure provides immunogenic compositions useful in prevention and treatment ofinfection. In particular, the disclosure provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal superantigen (SAg) proteins, or any fragments, variants, or derivatives thereof fused together as a single polypeptide in any order.

Immunogenic composition comprising a fusion peptide derived from superantigen toxoids

The present disclosure provides immunogenic compositions useful in prevention and treatment ofinfection. In particular, the disclosure provides methods of inducing an immune response against a LukAB-expressingmethods of preventing or treatinginfections, and composition for preventing or treatinginfections.

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This disclosure provides a comprehensive approach to specifically target various immune functions to the site of infection by a variety of fusion proteins that consist of a bacteriolysin cell wall targeting domain (CWT) and an immune function mediating component (IFMC). The CWT targets the fusion protein to the bacterial surface leading to accumulation at the site of infection. The IFMC mediates various immune functions such as toxin neutralization or recruitment of immune cells that can clear the bacteria.

Targeting immunological functions to the site of bacterial infections using cell wall targeting domains of bacteriolysins

This disclosure provides a comprehensive approach to specifically target various immune functions to the site of infection by a variety of fusion proteins that consist of a bacteriocin cell wall targeting domain (CWT) and an immune function mediating component (IFMC). The CWT targets the fusion protein to the bacterial surface leading to accumulation at the site of infection. The IFMC mediates various immune functions such as toxin neutralization or recruitment of immune cells that can clear the bacteria.

The present disclosure provides immunogenic compositions useful in prevention and treatment ofinfection. In particular, the disclosure provides delta toxin and phenol-soluble modulin peptides as well as mutants, fragments, variants or derivatives thereof. The disclosure further provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal proteins, e.g., DT, PSM, alpha hemolysin, leukocidin, superantigen, or any fragments, variants, derivatives, or mutants thereof fused together as a single polypeptide in any order.

Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof

The present disclosure provides immunogenic compositions useful in prevention and treatment ofinfection. In particular, the disclosure provides methods of inducing an immune response against a panton-valentine leukocidin (PVL)-expressing, methods of preventing or treatinginfections, and composition for preventing or treatinginfections.

Immunogenic composition comprising Panton-Valentine Leukocidin (PVL) derived polypeptides

The present invention provides immunogenic compositions useful in prevention and treatment ofinfection. In particular, the present invention provides methods of inducing an immune response against an alpha-hemolysin-expressing, methods of preventing or treatinginfections, and composition for preventing or treatinginfections.

Growing community of inventors

Gaithersburg, MD, United States of America

Rajan Prasad Adhikari