Sun Pharma Advanced Research Company Limited

Rajan Kumar Pal

Trinadha Rao Chitturi

Jayraj Dilipbhai Aradhye

Bhavesh Mohanbhai Panchal

Biswajit Samanta

Sandeep Pankajkumar Pathak

Kaushik Dhanjibhai Prajapati

A selective estrogen receptor degrader (SERD), a compound 3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, and its S enantiomer, (2S)-3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, or pharmaceutically acceptable salts thereof. Also provided are processes for their preparation. Also provided for is the use of these compounds for the treatment of diseases which are related to modulation of estrogen receptors, such as ER-positive breast cancer.

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Vadodara, India

Rajan Kumar Pal