Navinta, LLC

Navinta Iii Inc

Raja Jeyakumar John Muthiah

Jigneshkumar Jasubhai Patel

Pankaj Vasudev Parmar

Jagdish Kanjibhai Solanki

Vikas Kantilal Chauhan

Jigneshkumar Jasuhai Patel

Processes that use novel reagents for the removal of colored impurity during the preparation of Salcaprozic Acid and pharmaceutically acceptable salts thereof. The processes include hydrolysis of 8-(2,4-dioxo-1,3-benzoxazin-3-yl)octanoic acid ethyl ester in the presence of or by contacting it with benzotriazole, hydrazine and/or sodium borohydride.

Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof

Dicyclohexylamine salt of fosaprepitant (fosaprepitant DCHA), a process for preparing fosaprepitant DCHA, and a use of fosaprepitant DCHA in the preparation of pharmaceutically acceptable fosaprepitant dimeglumine with high purity is provided. Fosaprepitant dimeglumine is prepared by treating fosaprepitant DCHA with an acid to form fosaprepitant, followed by adding N-methyl-D-glucamine to fosaprepitant.

Crystalline fosaprepitant dicyclohexylamine salt and its preparation

The present invention provides dicyclohexylamine salt of fosaprepitant (fosaprepitant DCHA), a process for preparing fosaprepitant DCHA, and a use of fosaprepitant DCHA in the preparation of pharmaceutically acceptable fosaprepitant dimeglumine with high purity. Fosaprepitant dimeglumine is prepared by treating fosaprepitant DCHA with an acid to form fosaprepitant, followed by adding N-methyl-D-glucamine to fosaprepitant.

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Vadodara, India

Raja Jeyakumar John Muthiah