Reshape Lifesciences Inc.

Onciomed, Inc.

Onclomed, Inc.

Spinofix, Inc.

Armistice Capital Master Fund Ltd.

Raj Nihalani

Jonathan J Waataja

Reynz Delina

Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, are used to modify the secretion of insulin and glucagon from the pancreas, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating are used to control sensitivity of the liver to plasma insulin and glucagon to treat impaired glucose regulation.

Simultaneous multi-site vagus nerve neuromodulation for improved glycemic control system and methods

A gastric vest system for treating excessive weight or obesity in mammals. The gastric vest system may include a trapezoidal-shaped vest having a left edge, a right edge, an upper indentation, and a lower indentation, and the trapezoidal-shaped vest is configured to be wrapped around a stomach or a modified stomach of a mammal to cover a lesser curvature and a greater curvature of the stomach or the modified stomach.

Gastric vest for restriction of the stomach to treat obesity

A gastric restriction device for treating excessive weight or obesity in mammals. The gastric restriction devices includes a skirt having a left portion, a right portion, a top edge with a first indentation located at a center of the top edge, and a bottom edge with a second indentation located at a center of the bottom edge. The skirt has a narrow surface located between the first indentation and the second indentation and a broad surface formed from the left portion connecting to the right portion. The skirt is configured to envelop and fit a stomach of a mammal. The gastric restriction devices includes a first attachment device and a second attachment device. The second attachment device is adapted to engage the first attachment device so that the skirt envelops and fits the stomach of the mammal.

Gastric restriction devices for treating obesity

The invention generally relates to a method and apparatus to treat obesity and controlling weight gain. In an exemplary embodiment, the invention relates to a covered cage device that is implanted within a human's stomach to occupy volume and cause a reduced desire for eating. The covered cage device is made from a wire-mesh, such a Nitinol, and can be adjustable and collapsible. In another embodiment, the covered cage device has edges that provide stimulation to the stomach to induce a feeling of fullness.

Method and apparatus for treating obesity and controlling weight gain using self-expanding intragastric devices

A gastric restraining device for treating excessive weight or obesity in mammals. The gastric restraining device includes an elastomeric sheet configured to be placed around a stomach of a mammal, an ablation device attached to the elastomeric sheet, the ablation device configured to emit energy toward an outer surface of the stomach when the elastomeric sheet is placed around the stomach, and an energy device coupled to the ablation device to generate the energy and to transfer the energy to the ablation device.

The invention relates to a gastric restraining device for treating excessive weight or obesity in mammals. The gastric restraining device includes an elastomeric sheet configured to be placed around a stomach of a mammal, an ablation device attached to the elastomeric sheet, the ablation device configured to emit energy toward an outer surface of the stomach when the elastomeric sheet is placed around the stomach, and an energy device coupled to the ablation device to generate the energy and to transfer the energy to the ablation device.

Gastric restriction devices with fillable chambers and ablation means for treating obesity

The present invention may include a pedicle screw with a multifunctional adaptor, a strain reliever, and a dual-surface cap. The multifunctional adaptor may include a convex pivot ring for improving multi-axial movement and locking stability, an integrated locking mechanism for improving maneuverability, and an integrated compression member for improving the assembly process. The strain reliever may be formed along a neck of the pedicle screw for relieving mechanical stress asserted thereto, and thereby preventing a breakage thereof. The dual-surface cap may provide a slightly sloped surface for reducing the tension of the stabilizing rod. The present invention may also provide for a dynamic adaptor for flexibly connecting two stabilizing rods, which may be versatilely adapted to various pedicle screw configurations.

Pedicle screws and dynamic adaptors

The invention generally relates to a method and apparatus to treat obesity. In an exemplary embodiment, the invention relates to tucking a portion of the greater curvature of the stomach inwards, and covering the stomach around the greater curvature and lesser curvature with a silicone skirt to induce satiety and reduce the volume of the stomach body.

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Irvine, CA, United States of America

Raj Nihalani