Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Rainer Wehner

Johann Mattersberger

Helmut Lenz

Peter Sluka

Rolf Deeg

Udo Becker

Frederic Donie

Dagmar Klenner

Beatus Ofenloch-H&auml;hnle

Gerlinde Deutsch-Weyer

The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid a hook effect. The invention in addition concerns suitable reagent kits for carrying out the method.

Interference reduction by rheumatoid factors

A method for detecting an analyte is disclosed in which the analyte is brought into contact with at least one receptor which is bound to or can be bound to a solid phase. In order to avoid unspecific interferences the addition of a glycosidic surfactant is proposed.

Method and agent for the detection of an analyte containing glycosidic

The present invention provides a method for the determination of a component of an immune reaction in a plasma sample using an immunoassay at a temperature of from 15.degree. to 40.degree. C., where one of the reactive components is in solid phase. The invention involves adding an amount of plasminogen activator sufficient to eliminate interference by fibrinogen with the component to be determined.

Process for the determination of a component of an immune reaction in a

The present invention provides a process for stabilizing the activity of peroxidase in solution by the addition of a specific activity stabilizer, wherein, to the enzyme present in solid or dissolved form, there is added, as activity stabilizer, phenol which optionally contains one or more substituents selected from lower alkyl radicals and chlorine and bromine atoms, in an amount of from 0.0005 to 2% by weight, referred to the solution.

Process for stabilizing the activity of peroxidase in solution

The present invention provides a process for the determination of peroxidase by the addition of a peroxide and of a chromogen and measurement of the color resulting from the oxidation of the chromogen, the color formation being stopped after a definite time by the addition of a stop agent, wherein catalase is used as stop agent.

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Tutzing, Germany

Rainer Wehner