Basf Aktiengesellschaft

Basf Se Corporation

Basfaktiengesellschaft

Rainer Stürmer

Bernhard Hauer

Thomas Friedrich

Hartwig Schröder

Michael Breuer

Kurt Faber

Kai-Uwe Baldenius

Maria Keβeler

Rocco Paciello

Gunnar Heydrich

Wolfgang Ladner

Horst Weiss

Wolfgang Kroutil

Christoph Jäkel

Susanne Steiger

Michael Geprags

Christoph Nübling

Dejana Drew

Wolfgang Siegel

Klaus Ditrich

Franz Langhauser

Kurt Ritter

Uwe Meisenburg

David Fischer

Hagen Jaedicke

Paul Knochel

Hans-Herbert Brintzinger

Jurgen Kerth

Gunther Schweier

Bernhard Bockstiegel

Tilo Habicher

Klaus Krämer

Nina Schneider

Lothar Laupichler

Norbert Zimmermann

Jun Okuda

Melanie Hall

Detlef Ruff

Gerhard Klebe

Gudrun Voss

Jens Holz

Bettina Rosche

Katrin Schmidt

Karin Schein

Maria Kesseler

Clemens Stückler

Jürgen Däuwel

Wolf-Rüdiger Krahnert

Carsten Siedenbiedel

Falk Langer

Bettina M Nestl

Marco Bocola

Markus Matuschek

Bernhard Haur

Christian Gruber

Sabine Rinck

Andreas Schädler

André Mueller

Susanne Sabrowski

Hartwig SCHRÖDER

Sabine Rinck-Jahnke

Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which in which Rand Rhave the meanings given above and Rstands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim

Amidase and use thereof for producing 3-aminocarboxylic acid esters

A process for preparing optically active 2-methylalkan-1-ol of the general formula (III) comprising the following steps: 

Method for producing optically active 2-methyl-alkanols

The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.

Process for the reduction of cinnamaldehyde derivative employing enoate reductases

The invention relates to a process for preparing urethane-containing acrylic- and (meth)acrylic esters by reacting a urethane-containing alcohol with a reactant acrylic- or (meth)acrylic ester of a saturated alcohol in the presence of at least one polymerization inhibitor and an enzyme as a catalyst within a reactor, wherein the saturated alcohol released in the process and optionally an entraining agent form an azeotrope with an excess of the reactant (meth)acrylic ester, such that the azeotrope is removed by distillation under reduced pressure and at least one substream from the bottom of the reactor is circulated through the top of the distillation column. Using this process, urethane-containing acrylic- and (meth)acrylic esters are prepared in high yields and high purities under mild conditions from economically obtainable reactants with no significant polymer formation.

Process for preparing urethane-containing (meth)acrylic esters

A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3.

Process for enzymatic reduction of alkene derivatives

The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), wherein Rrepresents H, C-C-alkyl, C-C-alkenyl, or an optionally substituted carbocyclic or heterocyclic, aromatic or non-aromatic group, Rrepresents H, C-C-alkyl, C-C-alkenyl, by reaction in the presence of special reductases.

Method for the enzymatic reduction of alkyne derivates

A process for preparing optically active saturated aldehydes or alcohols of the formula (2) from &#x3b1;,&#x3b2;-unsaturated aldehydes of the formula (1) by reduction in the presence of an enoate reductase

Process for the enzymatic preparation of citronellal

A process for the racemization of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of

Biocatalytic racemisation of alpha-hydroxyketones

The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.

Method for the production of optically-active alcohols

The invention relates to novel proteins from, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.

Butynol I esterase

A process for preparing optically active alkanols of the formula I  

Enzymatic reduction for producing optically active alcohols

Method for producing an optically active 2-methyl-alkane-1-ol from the corresponding 2-methylalk-2-en-1-al, comprising carbonyl-selective reduction, enantioselective hydration and lipase-catalyzed, stereoselective acylation in order to enrich the desired

A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.

Process for the racemization of optically active secondary alcohols with the use of two alcohol dehydrogenases

The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and Rrepresents halogen, SH, OH, NO, NRRor NRRRX, wherein R, Rand Rindependently represent H or a lower alkyl or lower alkoxy group and Xrepresents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and Rare defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced. 

Method for producing optically active alcohols from alkanones using a dehydrogenase of azoarcus

A method for preparing substantially enantiopure 3-hydroxy carboxylic acids or esters of the general formula (III) by reacting racemic oxetan-2-ones of the general formula (I) with compounds R3-OH of the general formula (II) in the presence of a lipase fromor, and separating the resulting products of the formula (III) and (IV) from one another where the radicals have the following meaning:R, R, Rindependently of one another H; C-C-substituted or unsubstituted alkyl, substituted or unsubstituted aryl or hetaryl, where Rand Rmay not simultaneously have the same meaning.

Method for enantioselectively opening oxetan-2-ones

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Rödersheim-Gronau, Germany

Rainer Stürmer