Boehringer Ingelheim Kg

Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Gmbh

Boehringer Ingelheim Pharma Kg

C. H. Boehringer Sohn

Rainer Sobotta

Herbert Merz

Joachim Mierau

Rudolf Bauer

Adolf Langbein

Franz Dietrich Klingler

Armin Rapp

Hans-Peter Ignatow

Peter Sieger

Claus S Schneider

Hans Michael Jennewein

Rolf Schmid

Gunter Schingnitz

Heinrich Schneider

Manfred Psiorz

Reiner Ramert

Franz Dietrich Klinger

Wolfgang Broeder

Rainer Schwarz

Franz-Dietrich Klingler

Wolgang Broeder

Armin Walter Rapp

The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate. 

Benzimidazole derivative

Process for the preparation of a benzimidazole derivative

Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.

3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl) phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as a medicament

The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.

Process for manufacturing of chiral lobelin

The invention relates to a process for preparing N-substituted 3&#x3b2;-aminonortropanes of formula I wherein Rhas the meaning given in the claims, from the corresponding 3-oxonortropane or the corresponding 3&#x3b1;-aminonortropane, in which the latter is converted with an arylmethylamine or an arylaldehyde into the corresponding imines which are then tautomerised or isomerised and then hydrolysed. The invention also relates to the new compounds of formula V wherein Rand Ar have the meanings given in the claims.

Process for preparing N-substituted 3-&#x3b2;-aminonortropanes

The invention relates to a process for obtaining and purifying pure &#x3b1;-mangostin from the rind of the fruit (mangosteen) of

Process for isolating of &#x3b1;-mangostin

Process for the manufacture of tropenol

Process for purifying 20(S)-camptothecin

The present invention relates to a new and improved process for preparing 2-amino-6-chloropurine comprising the step of reacting guanine in the presence of ammonium sulphate with hexamethyldisilazane. The process of this invention advantageously results in a high yield of 2-amino-6-chloropurine and may be carried out on a laboratory or an industrial scale.

Process for preparing 2-amino-6-chloropurine

A method of preparing sugar acetonides, such as for example 1,2:5,6-Di-O-isopropylidene-.alpha.-D-glucofuranose, by reacting the corresponding sugar, e.g. D-(+)-glucose, with acetone in the presence of a Lewis acid and a carboxylic acid derivative of general formula ##STR1## wherein X is a leaving group which may be readily replaced by a hydroxyl group.

Process for preparing sugar acetonides

The invention is directed to a process for preparing a 1,3-dialkyl-5-hydroxyoxindole of formula 1: ##STR1## comprising heating an N-alkyl-p-alkoxy-(.alpha.-haloacyl)anilide of formula 2: ##STR2## wherein the substituents are as defined herein, in the presence of an anhydrous zinc halide to a temperature in the range from about 120.degree. C. to about 160.degree. C., and isolating the 1,3-dialkyl-5-hydroxyoxindole prepared.

Process for preparing 1,3-dialkyl-5-hydroxyoxindoles and the ether

The present invention relates to an improved process for preparing 1,2-5,6-diacetone-D-glucose from D-glucose and diketene or the adduct of diketene with acetone.

Process for preparing 1,2-5,6-diacetone-D-glucose

The present invention relates to a new process for preparing enantiomerically pure diarylprolinols, especially (R)-(+)- or (S)-(-)-2-(diphenylhydroxymethyl)-pyrrolidine (R)-(+)- or (S)-(-)-.alpha.,.alpha.-diphenyl-(2-pyrrolidinyl)-methanol) starting from proline.

Process for preparing enantiomerically pure diarylprolinols

Process for the racemization of nonracemic 3-oxyocylopentane- or

3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.

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Ingelheim am Rhein, Germany

Rainer Sobotta