Roche Diagnostics Operations, Inc.

Airbus Operations Gmbh

Airbus Deutschland Gmbh

Sanofi-a Ventis Deutschland Gmbh

Airbus (sas)

Daimler-benz Aerospace Airbus Gmbh

Daimlerchrysler Aerospace Airbus Gmbh

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Rainer Mueller

Johann-Peter Thalhofer

Harald Sobek

Werner Hoelke

Frank Geipel

Bernhard Suppmann

Manfred Schmidt

Thomas Kirschbaum

Michael Greif

Stephan Glaser

Thomas Scherer

Alfred Engel

Marco Thomann

Sebastian Malik

Peter Turanski

Christine Jung

Wilko Oestereich

Stephanie Ronning

Georg Muehlthaler

Sven Uhlemann

Thorsten Reinelt

Markus Pajatsch

Erhard Kopetzki

Helmut Lenz

Helmut Schwab

Rainer Schmuck

Bruno Frey

Jan Dittmar

Heinz-Peter Busch

Marc Wesseloh

Frank Zocher

Bettina Bommarius

Markus Kerber

Bernd Schneidinger

Robert Redecker

Bernd Nidetzky

Hellmut Eckstein

Claudia Giessel

Jens Elmers

Armin Ruf

Andreas Holm

Marc Hoelling

Helmut Schoen

Bernhard Rexer

Wolfgang Hoesel

Kirsten Sonn

Ingo Curdt

Christiane Luley

Christian Rudolph

Michael Ratka

Heiko Luetjens

Tibor Czabany

Doris Ribitsch

Katharina Schmoelzer

Sabine Zitzenbacher

Robert Huebner

Marie-Laure Wawrzyniec

Stefan Nill

Christoph Hoh

Beata Kanne

Peter Pallua

Claus Schneider

Elvira Wolf

An insulation pack for thermally and acoustically insulating an aircraft has a mat formed from an insulation material, and a casing film which completely encases the mat. The casing film has drying openings, each closable a cover that is connected to the casing film. Each cover has a coating substance, the planar extent of which varying as a function of the relative air humidity of the air in the interior of the insulation pack such that each cover moves relative to the casing film, as a function of air humidity. The associated covers are adapted for assuming an orientation which, below a predetermined relative air humidity, closes the associated drying opening and which, at higher relative air humidity values, at least partially opens the associated drying opening.

Insulation pack having drying openings, for thermally and acoustically insulating an aircraft

An aircraft fuselage includes at least one space arranged in the aircraft fuselage and at least one wall. The wall resists burnthrough for a period of at least four minutes from outside the aircraft fuselage towards the space, wherein the region of the aircraft fuselage underneath the space does not include burnthrough-resistant insulation. The space may be a cargo compartment of the aircraft or a passenger cabin, while the wall may be designed as a cargo compartment floor, passenger cabin floor or wing/fuselage fairing (belly fairing). The design of the aircraft fuselage results in burnthrough resistance that meets the requirements of FAR &#xa7;25.856 (b) without any additional burnthrough-resistant insulation in the aircraft fuselage.

Aircraft fuselage having burnthrough resistant components

The present disclosure is directed to the use of certain glycosyltransferase variants having N-terminal truncation deletions. Contrary to previous findings certain truncations were found to exhibit sialidase enzymatic activity, particularly a variant of human sialyltransferase (hST6Gal-I) with a truncation deletion involving the first 89 N-terminal amino acids of the respective wild-type polypeptide. A fundamental finding documented in the present disclosure is that there exists a variant of this enzyme which is capable of catalyzing transfer of a glycosyl moiety as well as hydrolysis thereof. Thus, disclosed is a specific exemplary variant of mammalian glycosyltransferase, nucleic acids encoding the same, methods and means for recombinantly producing the variant of mammalian glycosyltransferase and use thereof, particularly for sialylating in a quantitatively controlled manner terminal acceptor groups of glycan moieties being part of glycoproteins such as immunoglobulins.

Quantitative control of sialylation

The present disclosure is directed to the use of certain glycosyltransferase variants having N-terminal truncation deletions. It was found that the combination of two different truncation variants of human &#x3b2;-galactoside-&#x3b1;-2,6-sialyltransferase I (hST6Gal-I) exhibited different specific sialyltransferase enzymatic activities. In one example, under conditions wherein the first variant &#x394;89 hST6Gal-I catalyzed formation of bi-sialylated target molecules the second variant &#x394;108 hST6Gal-I catalyzed formation of mono-sialylated target molecules. Thus, disclosed are variants of mammalian glycosyltransferase, nucleic acids encoding the same, methods and means for recombinantly producing the variants of mammalian glycosyltransferase and use thereof, particularly for sialylating in a quantitatively controlled manner terminal acceptor groups of glycan moieties being part of glycoproteins such as immunoglobulins.

Quantitative control of sialylation and specific mono-sialylation

A vehicle window with a primary window pane arrangement, a secondary window pane that is spaced apart from the primary window pane arrangement and a window funnel that extends between the secondary window pane and the primary window pane arrangement is provided. The vehicle window includes an intermediate space that is formed by the window funnel, the secondary window pane and the primary window pane arrangement, and the intermediate space is sealed and equipped with an air inlet for introducing dehumidified air into the intermediate space. Due to the seal, humid air leading to condensation and frost in the intermediate space is prevented from flowing into the intermediate space during a pressure compensation flow. The passenger comfort is enhanced due to the improved view through the window.

Non-fogging vehicle window

An insulation arrangement with two or more insulation packages that overlap such that at least one overlapping region is formed and are arrangeable on a fuselage wall is provided. The insulation packages comprise an insulating material and welded cover films. The cover films are realized in an airtight and waterproof fashion and comprise ventilation openings on a side that is directed toward the fuselage wall in an overlapping region. In this way, pressure variations in the insulation packages can be compensated with relatively dry air that originates from a gap between the insulation packages and the fuselage wall in order to thusly reduce the accumulation of condensation water in the insulation packages.

Insulation arrangement with ventilation openings for aircraft

An insulation arrangement for thermally and acoustically insulating an aircraft fuselage, which comprises at least one insulation packet arranged on an exterior skin of the aircraft. The insulation packet includes dimensionally rigid foam, and comprises a shape corresponding at least with a structural component on the exterior skin, as the result of which the insulation packet is retained on the structural component even without any additional attachment elements. As a result, ventilation openings need not be provided, thereby reducing condensation water accumulating in aircraft insulation.

Condensation water-free insulation system for passenger aircraft

The present invention provides improved variants of T7 RNA polymerase by introducing novel mutations which lead to improved thermostability of the enzyme. According to the invention, amino acid substitutions at the positions Val426, Ser633, Val650, Thr654, Ala702, Val795, and combinations thereof are advantageous.

T7 RNA polymerase variants with enhanced thermostability

An insulation package is provided for insulating a cabin of a vehicle that includes, but is not limited to at least one wrapping foil and at least one core layer of an insulation material. The wrapping foil envelopes the core layer at least in some regions and includes, but is not limited to at least one opening for feeding-through a holding element. On the wrapping foil a fastening element is arranged that is designed to establish a mechanical connection with the holding element fed through the opening. This can be a positive-locking or a non-positive-locking connection. By integrating the fastening element in the insulation package, the expenditure for separate fasteners can be saved so that the installation time and the different components can be reduced.

Insulation package for insulating a cabin of a vehicle

The invention relates to an aircraft side fairing, with a component () in the form of individual hollow chambers () which are arranged essentially in a preferably curved plane and are arranged between two cover layers (), wherein a gastight film which completely encases the component () with the hollow chambers () is provided and, after application of a vacuum to evacuate the hollow chambers (), surrounds the component () with the hollow chambers in a gastight manner.

Aircraft side fairing

The present invention provides an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase. The present invention further provides a method of stabilizing an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase, and a method of preparing a purified aqueous composition comprising the protein with enzymatic activity of alpha-galactosidase.

Stabilized aqueous alpha-galactosidase composition and methods relating thereto

The present invention relates to a method for insulating an aircraft cabinand for the cooling or heating of cabin air in an aircraft, respectively with the method comprising the steps of: introducing aircraft cabin air into an aircraft cabin wall; guiding this aircraft cabin air along a section of this aircraft cabin wall; and leading this aircraft cabin air away from the aircraft cabin wall

Method for isolating a cabin wall of an aircraft or for cooling or heating of cabin air and a cabin wall suitable therefore

The design and attachment of an insulation package near the fuselage structure to protect the cabin region of an aircraft against fire acting on the insulation package from outside the aircraft environment, thus clearly facilitating evacuation of the passengers from the vehicle. The insulation package arrangement may comprise several fuselage insulation packages of an elongated form. These packages may adjoin the aircraft fuselage structure in the direction of the longitudinal axis of the aircraft. They may be completely enclosed by a burn-through-proof foil which is arranged in a space enclosed by interior paneling and by the panels of the outer skin. The longitudinal end of the fuselage insulation package continues outward with a flat insulation end section is attached which is attached to a rib-attachment region arranged below the respective longitudinal sides of a rib and near the stringer by means of burn-through-proof attachment elements arranged on the inside of the aircraft with respect to the insulation.

Insulation package arrangement for insulating the interior of an aircraft fuselage

The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non-animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their production. Also provided are use of recombinant porcine pancreatic trypsin variants for cleavage of precursors of insulins, and kits containing the variant of trypsin.

Cleavage of precursors of insulins by a variant of trypsin

The present invention relates to an insulation structure for the internal insulation of a vehicle. The insulation structure is improved in such a way that using it a fire incursion of the flames of a source of fire acting from outside the vehicle environment into the vehicle interior is excluded as much as possible, an increase of the fire protection safety for separate interior regions lying proximal to a structure external skin being implemented by the type of the film insulation of the insulation package. The insulation structure comprises an insulation package (), in which an insulation core () is embedded, and a film (). The insulation package () is positioned inside an intermediate space which encloses internal paneling and an external skin. It is completely enclosed by the film (). The film () is implemented using a burn-through safe film material, which is an obstruction to a flaming fire, to which a film surface region of this film is subjected during an occurring fire catastrophe.

Insulation arrangement for the internal insulation of a vehicle

Growing community of inventors

Rosengarten, Germany

Rainer Mueller