Sandoz Gmbh

Trigen Gmbh

Thrombosis Research Institute

Rainer Metternich

Goran Karl Claeson

Manfred Hans Philipp

Georg Kottirsch

Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X.dbd.H or is an N-protecting group; Y is 1-10 .alpha.-amino acids; Q1 and Q2 taken together represent the residue or a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L-configuration, are useful in therapeutic methods of inhibiting thrombin.

Inhibitors of trypsin-like enzymes

Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X=H or is an N-protecting group; Y is Phe-Pro; Q1 and Q2 taken together represent the residue of a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L- configuration, are useful in therapeutic methods of inhibiting thrombin.

Pseudopeptides of formula I in free or salt form ##STR1## wherein A, B, R.sub.1, X, Y and m are defined as in claim 1, and their use in the prophylactic and acute treatment of thrombosis.

Pseudopeptide isosteres of gly-asp and their use as antithrombic agents

Borolysine peptidomimetics of formula I ##STR1## wherein W, Y, R.sub.4, R.sub.5, Q.sub.1 and Q.sub.2 are defined in claim 1 are potent thrombin inhibitors.

Growing community of inventors

Inzlingen, Germany

Rainer Metternich