Hoechst Aktiengesellschaft

Hoechst Aktiengesellschafat

Rainer Henning

Hansjorg Urbach

Volker Teetz

Reinhard Becker

Bernward Scholkens

Rolf Geiger

Ulrich Lerch

Franz Hock

Wolfgang Ruger

Hermann J Gerhards

Joachim Kaiser

Wolfgang Linz

Adalbert Wagner

Wolf-Ulrich Nickel

Holger Heitsch

Dieter Ruppert

Holger Gaul

Jean-Paul Vevert

Hans Wissmann

Josef Scholtholt

Gabriele Wiemer

Jean-Claude Caille

Winfried Hertzsch

Heinz-Werner Kleemann

Wolfgang Scholz

Heinrich Christian Englert

Dieter Mania

Rudolf Lattrell

Heiner Jendralla

Patricia Usinger

Bernhard Seuring

Jens Stechl

Dietrich Langner

Hansj Org Urbach

Bernward Sch Olkens

Hans Jorg Urbach

Hans Wissman

Hansj/o/ Rg Urbach

Hansjorj Urbach

Raymond Oekonomopulos

The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

Method of treating cardiac insufficiency using angiotensin-converting

The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their preparation and their use as medicaments.

Combination of angiotensin-converting enzyme inhibitors with calcium

Method of treating cardiac insufficiency

Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their use Compounds of the formula (I) ##STR1## in which R.sup.1 is, for example, ethyl,

Imidazole derivatives with a biphenylsulfonylurea or

The invention relates to compounds of the formula I ##STR1## in which n is 1, 2 or 3,

Cis, endo-2-azabicycloalkane-3-carboxylic acid derivatives

The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof for angiotensin II receptors.

Substituted imidazoles

The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

Aminoacid derivatives of the formula I ##STR1## A , n, R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and salts thereof, a process for their preparation, pharmaceutical preparations based on these compounds, and their use as medicaments.

Aminoacid derivatives, a process for their preparation, agents

Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof The invention relates to renin-inhibiting amino acid derivatives of the formula ##STR1## in which R.sup.1 is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO.sub.2 or SO, Y is CH.sub.2, O or S, B is the radical of an amino acid of the formula H--B--OH, and R.sup.3, R.sup.4 and R.sup.5 are as defined in the description, a process for the preparation thereof, agents containing these, and the use thereof.

Amino acid derivatives with renin-inhibiting properties, a process for

A combination of angiotensin-converting enzyme inhibitors and calcium antagonists for the treatment of proteinuria is disclosed. The invention relates to the prevention and therapy of proteinuria by administration of a combination of ACE inhibitor and calcium antagonist.

Use of a combination of angiotensin-converting enzyme inhibitor and

The invention relates to compounds of the formula I ##STR1## in which A denotes a radical of the formula II ##STR2## in which E denotes a CH.sub.2 group or an NR.sup.9 radical,

Renin-inhibiting aminodiol derivatives

The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, R.sup.1 and R.sup.2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.

Substituted imidazoles, pharmaceutical compositions containing these,

Two processes are described for the preparation of the optically pure compounds of formula 1: ##STR1## in which R.sup.1 and R.sup.2 are e.g. alkyl, R.sup.3 and R.sup.4 are e.g. hydrogen and R.sup.5 is e.g. hydrogen. Both processes include, as key steps, the enantioselective hydrogenation of a C.dbd.C double bond and the regioselective formation of a dicarboxylic acid monoamide derivative. In one process a phenylitaconic acid derivative is asymmetrically hydrogenated to give an optically active (R)-benzylsuccinic acid which is then converted to a diester, said diester being converted to the monoamide compound of formula 1. In the second process, a phenylitaconic acid derivative is converted to its anhydride, and the anhydride is then converted to a monoamide which is then asymmetrically hydrogenated to give the compound of formula 1.

Process for the enantioselective synthesis of 2(R)-benzylsuccinic acid

The invention relates to a pharmaceutical composition comprising an angiotensin converting enzyme inhibitor (trandolpril or pamipril) and a loop diuretic (Furosemide or piretanide), and to their use for the treatment of high blood pressure.

Pharmaceutical composition for the treatment of high blood pressure

Growing community of inventors

Hattersheim am Main, Germany

Rainer Henning