Freie Universitat Berlin

Freie Universitaet Berlin

Tel Aviv University

The University of British Columbia

Oxford University Innovation Ltd

Biolitec Unternehmensbeteiligungs II Ag

Mivenion Gmbh

Dendropharm Gmbh

Harvard College

Humboldt-universität Zu Berlin

Universität Dortmund

Vergell Medical S.a.

Biolitec Holding Gmbh & Co Kg

Fu Berlin

Epiios Therapeutics Gmbh

Rainer Haag

David A Weitz

Felix Kratz

Marie Weinhart

Ronit Satchi-Fainaro

Paula Ofek

Qiang Wei

Wiebke Fischer

Florian Paulus

Volker Albrecht

Donald Elliott Brooks

Jayachandran N Kizhakkedathu

Kai Licha

Arno Wiehe

Wolfgang Friess

Burkhard Gitter

Susanna Gräfe

Ingo Grunwald

Michael Schirner

Carol Robinson

Uwe Landau

Rajesh Shenoi

Susanna Graefe

Christoph Stein

Kevin Pagel

Hsin-Yung Yen

Sam Moré

Abdul Mohiuddin Quadir

Michael Unbehauen

Madeleine Witting

Andreas Nitsche

Sabine Reimann

Andreas Zielonka

Jens Dernedde

Uwe Schedler

Emanuel Fleige

Benjamin Lai

Michael Staegemann

Dominic Groeger

Svenja Christina Ehrmann

Leonhard Hagen Urner

Idlir Liko

Halina Machelska-Stein

Tobias Becherer

Leixiao Yu

Pia Welker

Mohiuddin Abdul Quadir

Dirk Steinhilber

Sarah Küchler

Yu Leixiao

Carol V Robinson

Yinan Zhong

Daniel Braatz

Halina Machelska

Kerstin HÖGER

Sarah Hedtrich

Michal Radowski

Tang Peng

Michael KRÄMER

Mohiuddin Quadir

Mathias Dimde

Ronit Satchi - Fainaro

Carina Treiber

Magda Ferraro

Ehsan Mohammadifar

Benjamin Ziem

Daniel Lauster

Fatemeh Zabihi

Mohsen Adeli

Mohammad Suman Chowdhury

Marcelo Calderón

Gerd Multhaup

Teodora Valkova

Wenzhong Li

Wanjun Liang

Andreas Herrmann

Sumati Bhatia

A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a dendritic detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; vaporising the solution using the nanoelectrospray ionisation source; ionising the protein; resolving the ionised protein using the mass analyser; and detecting the resolved protein using the detector. A method of extracting a membrane protein from its native membrane comprises: providing a membrane protein in its native membrane; contacting the membrane protein with a dendritic detergent. Dendritic detergents for use in the methods are also provided.

Dendritic detergents for the analysis of proteins by mass spectrometry

The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.

Analgesic preparation with nanocarriers and use thereof

The disclosure relates to an amphiphilic block copolymer comprising a first block consisting of a polymeric hydrophilic domain, wherein the polymeric hydrophilic domain consists of a polyglycerol; an optional second block consisting of a hydrophobic domain and a first linker domain, wherein the second block is covalently bound to the first block via the first linker domain, an optional third block consisting of a catechol domain and a second linker domain, wherein the third block is covalently bound to the first block via the second linker domain; and a fourth block consisting of a crosslinking domain and a third linker domain, wherein the fourth block is covalently bound to the first block via the third linker domain, wherein the crosslinking domain comprises a reactive residue enabling a crosslinking between individual molecules of the amphiphilic block copolymer.

Amphiphilic block copolymer and coating arrangement

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. In addition, conjugates are provided in which these photosensitizers are attached to water-soluble polymers via cleavable linkers that can be cleaved in the body under specific conditions. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

Conjugates of porphyrinoid photosensitizers and glycerol-based polymers for photodynamic therapy

It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.

Polyglycerol derivative and a method for manufacturing the same

The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.

Anionic linear polyglycerol derivatives, a method for manufacturing and applications

An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.

Bioinert article and its use

A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.

Method for producing a polyglycerol nanogel for the encapsulation and release of biologically active substances

The invention relates to a compound suited as entity carrier, having the general formula (I) wherein X is an amine-containing residue further defined herein. The invention further relates to the use of such compounds, a nanocarrier system, a kit comprising such compounds and methods for gene silencing and anti-cancer treatment.

Compounds suited as nanocarriers for active agents and their use

The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis

Growing community of inventors

Berlin, Germany

Rainer Haag