Sanofi-a Ventis Deutschland Gmbh

Rainer Gauler

Javier Manero

Frank Zocher

Tobias Metzenthin

Wolfgang Laux

Hans-Wolfram Flemming

Rudolf Lehnert

Holger Berk

An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.

Method for the production of ramipril

The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.

Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use

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Frankfurt am Main, Germany

Rainer Gauler