Pharmacia & Upjohn Aktiebolag

Pharmacia Aktiebolag

Kabi Pharmacia Ab

Carmeda Ab

Rainer Eketorp

Per Tornblad

Robert Marschall

An apparatus and process for coating a plurality of articles in batches, in particular for applying a biocompatible layer on articles adapted to come into contact with blood or body tissue, e.g. a coagulation-preventing substance so as to render the articles non-thrombogenic. A plurality of article-carrying plates ( ) are stacked upon one another and have a plurality of communicating wells ( ) for receiving therein a respective article to be coated. A base plate ( ) defines with a bottom side of a lowermost of said article-carrying plates a distribution chamber ( ) for receiving and evenly distributing a solution containing a substance to be applied to said articles. The solution is fed through the wells of the stacked plates ( ) in parallel vertical flows.

Apparatus and process for coating articles

A method is provided for cleansing a protein from multivalent metal ions bound thereto, these ions being released from the protein by exchanging the ions with monovalent metal ions, whereafter the multivalent metal ions are removed. The release and removal of these ions is effected, in particular, by diafiltration or gel filtration processes.

Method of cleansing a protein from multivalent metal ions bound thereto

One-step, one-container method for the preparation of pyridoxylated

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Danderyd, Sweden

Rainer Eketorp