Hoffmann-la Roche Inc.

Rainer Alex

Paul Hadvary

Hansjorg Tschirky

Thomas Rades

Ingeborg Kraemer-Pittrof

J&uuml;rgen Gerhards

Richard Oeschger

The present invention provides a process for encapsulating a shear sensitive fill mass which contains a pharmaceutical active agent or nutrient, characterized in that said fill mass is heated and subsequently cooled, prior to the encapsulation. The invention also provides capsules comprising shear sensitive fill material obtained by the said process which have a high and constant dissolution rate.

Process for encapsulating shear sensitive fill masses into capsules and capsules containing shear sensitive fill masses

An improved injection device has a casing containing an active substance reservoir, a cannula communicating with the reservoir, a device for inserting the cannula, and pump means for discharging the reservoir contents through the cannula. The cannula 11 is fixed relative to the casing and projects beyond the underside of the casing to the depth required for injection. The cannula is surrounded by a protective element which is moved by a spring drive from a first end position in which the protective device projects beyond the underside of the casing and beyond the cannula to a second end position in which the protective device does not project beyond the underside of the casing.

Dermally affixed injection device

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Weil am Rhein, Germany

Rainer Alex