Centro De Ingenieria Genetica Y Biotecnologia

Biorec S.a.

Raimundo Ubieta Gomez

Gerardo Enrique Guillen Nieto

Jorge Amador Berlanga Acosta

Diana Garcia Del Barco Herrera

Sonia Gonzalez Blanco

Luis Saturnino Herrera Martinez

Danay Cibrian Vera

Jose Ignacio Fernandez Montequin

Vivian Maria Saez Martinez

Osvaldo Reyes Acosta

Boris Ernesto Acevedo Castro

Merardo Pujol Ferrer

Maribel Guerra Vallespi

Lila Rosa Castellanos Serra

Hilda Elisa Garay Perez

Osmany Guirola Cruz

Ana Aguilera Barreto

Eulogio Pimentel Vazquez

Eduardo Martinez Diaz

Celia Berta Fernandez Ortega

Dionne Casillas Casanova

Rolando Paez Meireles

Taimi Emelia Paneque Guerrero

Marta Dubed Echevarria

Leonor Margarita Navea Leyva

Carlos Antonio Duarte Cano

Viviana Falcon Cama

Orlando Borras Hidalgo

Antonio Sereno Guerra

Anna Caridys Ramírez Suarez

Isis Del Torrens Madrazo

Luis Javier Gonzalez Lopez

Anna Caridys Ramirez Suarez

The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the the proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, including peptides and/or interfering RNA and/or lipidic compounds, the agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection.

Method for inhibiting HIV replication in mammal and human cells

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

Growing community of inventors

Ciudad de la Habana, Cuba

Raimundo Ubieta Gomez