Massachusetts Institute of Technology

Istituto Di Ricerche Chimiche E Biochimiche G Ronzoni

Momenta Pharmaceuticals, Inc.

Instituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Rahul Raman

Ram Sasisekharan

Ganesh Venkataraman

Kevin Pojasek

Zachary Shriver

Karthik Viswanathan

Carlos J Bosques

Nishla Keiser

Ishan Capila

Vikas Prabhakar

Giangiacomo Torri

Benito Casu

Marco Guerrini

Kannan Tharakaraman

Aarthi Chandrasekaran

Akila Jayaraman

Aravind Srinivasan

Xiaoying Koh

Viswanathan Sasisekharan

S Raguram

Nathan Wilson Stebbins

Pankaj Gandhe

Sasi Raguram

Zachary H Shriver

The present invention provides, among other things, systems (e.g., comprising compositions and/or methods) for diagnosis, prophylaxis, treatment, prevention, and/or characterization of influenza transmission and/or infection. The present invention also provides methods for monitoring influenza variants for their potential to present a pandemic risk to humans.

Human Adaptation of H7 HA

The present invention provides, among other things, technologies and methodologies for detection, treatment, and/or prevention of influenza transmission and/or infection. The present invention also provides technologies for monitoring influenza variants for their potential to present a pandemic risk to humans.

Human adaptation of H3 influenza

The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.

Hemagglutinin polypeptides, and reagents and methods relating thereto

The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.

Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines

The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., H1 HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., H1 HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.

Compositions and methods for diagnosing and/or treating influenza infection

The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.

Decoy influenza therapies

The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.

Chondroitinase ABC I and methods of degrading therewith

The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

Methods and products related to the improved analysis of carbohydrates

The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.

Method for sequence determination using NMR

Chondroitinase ABC I and methods of production

Chondroitinase ABC I and methods of analyzing therewith

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Cambridge, MA, United States of America

Rahul Raman