Symrise Ag

Basf Se Corporation

Rahim Brodhage

Claudia Gömann

Wolfgang Siegel

Ralf Pelzer

Thomas Subkowski

Michael Backes

Sven Siegel

Martina Herrmann

Heiko Oertling

Gabriele Vielhaber

Claus Bollschweiler

Imke Meyer

Arnold Machinek

Hubert Loges

Dominik Stuhlmann

Jens Wittenberg

Benoit Join

Jekaterina Ongouta

Martin Weisel

Nicole Titze

Karin Schaper

Nadine Hillebrand

Benoît Join

Susanne Mundt

Tom Somers

The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

Use of physiological cooling active ingredients, and compositions comprising such active ingredients

The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4 -alkenyl,

Cyclohexyl carbamate compounds as skin and/or hair lightening actives

The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof wherein The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to certain novel compounds of formula (I).

Menthyl carbamate compounds as skin and/or hair lightening actives

The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl,wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms,B denotes NRR, whereinRdenotes hydrogen or an organic radical having 1 to 14 carbon atoms,Rdenotes an organic radical having 1 to 14 carbon atoms, andwherein optionally Rand Rare covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.

Cyclohexyl carbamate compounds as active anti-cellulite ingredients

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Höxter, Germany

Rahim Brodhage