Eli Lilly and Company

University of North Carolina at Chapel Hill

Sorrento Therapeutics, Inc.

Raheleh Toughiri

Stephen John Demarest

Xiufeng Wu

Brian Arthur Kuhlman

Steven Morgan Lewis

Gunnar F Kaufmann

Bryan Edward Jones

Yanwen Fu

The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (V/V) domain and the heavy chain-light chain constant (C/C) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Methods for producing Fabs and bi-specific antibodies

There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.

Chemically-locked bispecific antibodies

The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (V/V) domain and the heavy chain-light chain constant (C/C] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Methods for producing fabs and bi-specific antibodies

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San Diego, CA, United States of America

Raheleh Toughiri