3m Innovative Properties Company

Raha A Been

James M Jonza

Joseph D Rule

Naimul Karim

David R Holm

Jason W Bjork

Badri Veeraraghavan

Alexi J Young

Andrew W Vail

Jennifer N Hanson

Petra L Kohler Riedi

Jana Ninkovic

Döne Demirgöz

Gregory J Anderson

Bryan A Baker

Döne DEMIRGÖZ

A viscoelastic wound closure dressing. The dressing can include a viscoelastic backing having a first major surface configured to face skin when in use, a first end, a second end, and a middle section located between the first end and the second end. The wound closure dressing can further include a skin-contact adhesive on the first major surface of the viscoelastic backing adjacent the first end and the second end. A majority of the first major surface of the middle section can be free of the skin-contact adhesive. The viscoelastic backing can recover, at room temperature: (i) no more than 40% of its deformation after 10 seconds, after being strained to 50% elongation for 30 minutes, and (ii) at least 70% of its deformation after 48 hours, after being strained to 50% elongation for 30 minutes.

Viscoelastic wound closure dressing

A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.

Fibrin composition, method and wound articles

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Wayzata, MN, United States of America

Raha A Been