Pronova Biopharma Norge As

Basf As

Ragnar Hovland

Tore Skjæret

Anne Kristin Holmeide

Morten Brændvang

David Alan Fraser

Morten Braendvang

David A Fraser

Morten BRÆNDVANG

Methods are disclosed to treat or prevent at least one disease or condition in a subject in need thereof comprising administering a compound of Formula (I):  or a pharmaceutically acceptable salt, or ester thereof, wherein Rand Rare independently chosen from a hydrogen atom or linear, branched, and/or cyclic C-Calkyl groups, with the proviso that Rand Rare not both hydrogen or a pharmaceutically acceptable salt or ester thereof. Such diseases or conditions may relate to coronary heart disease (CHD), for example atherosclerosis; metabolic syndrome/insulin resistance; and/or a dyslipidemic condition such as hypertriglyceridemia (HTG), elevated LDL-cholesterol, elevated total-cholesterol, elevated Apo B and low HDL-cholesterol. The present disclosure further provides for a method of reducing atherosclerosis development. Pharmaceutical compositions comprising a compound of Formula (I) are also disclosed.

Methods of treatment using lipid compounds

Methods for the efficient synthesis of fatty acid derivatives and their intermediates are provided.

Methods of preparing fatty acid derivatives

The present invention relates to lipid compounds of the general formula (I):  wherein Ris selected from a C-Calkyl, a C-Calkenyl having 1-6 double bonds, and a C-Calkynyl having 1-6 triple bonds; Rand Rare the same or different and may be selected from a group of different substituents; Y is selected from sulphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof. The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.

Sulphur containing lipids for use as food supplement or as medicament

The present disclosure relates to lipid compounds of the general formula (I):R1-O&#x2014;C(R2)(R3)-X&#x2003;&#x2003;(I)wherein Ris a C-Calkyl group, a C-Calkenyl group having 1-6 double bonds, or a C-Calkynyl group having 1-6 triple bonds; Rand Rare the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.

Growing community of inventors

Nesoddtangen, Norway

Ragnar Hovland