Chatham Biotec, Limited

Other

Conor Medsystems, Inc.

Shanghai Bioman Pharma Limited

Bn Pharmaceuticals Inc.

Ragina Naidu

Samuel Siang Kiang Foo

Yunman Zheng

Tianhui Xu

BaoYu Xue

Bo Fan

The invention provides new cabazitaxel isoserine ester intermediates and new synthetic methods, and a preparation method for the anti-tumour drugs cabazitaxel, docetaxel and paclitaxel from the new cabazitaxel isoserine intermediates.

Cabazitaxel, related compounds and methods of synthesis

A process is provided for the preparation of camptothecin derivatives, such as irinotecan, in a one-pot operation.

Process to prepare camptothecin derivatives

This invention relates to an improved semi-synthetic process for the preparation of taxane derivatives like paclitaxel, docetaxel, canadensol and its derivatives, the process, which has shorten reaction route, simple procedure, high yield and low materials cost, therefore facilitates the commercial manufacture of these derivatives.

Semi-synthetic process for the preparation of taxane derivatives

A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel

A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2', C-7 and C-10 positions and introducing a t-Boc group at the nitrogen of the amide group at the C-3&#x2032; position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.

Semi-synthetic conversion of paclitaxel to docetaxel

A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel

A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, the semi-synthesis of a mixture of 10-deacetylbaccatin III and baccatin III, and protected derivatives thereof, from a mixture of taxanes.

Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes

A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannine and baccatin III intermediates, and the conversion of such intermediates and analogues to paclitaxel and docetaxel.

Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel

A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.

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Burnaby, Canada

Ragina Naidu