Council of Scientific and Industrial Research

Raghunath Anant Mashelkar

Mohan Gopalkrishna Kulkarni

Bhalchandra Shripad Lele

Alankar Arun Vaidya

Rohini N Karmalkar

Manohar Virupax Badiger

Sanjay Malik

Satish N Shintre

Mohan Gopalkishna Kulkarni

Shyni Varghese

Ashish Kishor Lele

The present invention provides novel thermoprecipitating polymers of formula 1 containing novel enzyme sensitive ligands of the formula 4, processes for the preparation thereof respectively, and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, 1 is an integer in the range of from 1 to 10, m and n are either 0 or 1, x and y are integers greater than 1. 

Thermoprecipitating polymer containing enzyme specific ligands, process for the preparation thereof, and use thereof for the separation of enzymes

The present invention provides novel thermoprecipitating polymers of formula 1 containing novel enzyme sensitive ligands of the formula 4, processes for the preparation thereof respectively, and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, 1 is an integer in the range of from 1 to 10, m and n are either 0 or 1, x and y are integers greater than 1

The invention discloses a process for the preparation of polymeric absorbents useful for gelling organic liquids. The process comprises mixing one or more monomers with a cross-linking agent, a free radical initiator, an optional solvent, optionally in the presence of a transition metal source and subjecting the mixture so obtained to a conventional polymerisation method. The polymer is removed, crushed to obtain polymer powder, washed with solvent and dried by conventional methods to remove unreacted monomers, followed by swelling in alcohols to obtain the desired product.

Process for the preparation of polymeric absorbents

The present invention relates to a process for the preparation of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer comprising a spacer and a co-monomer with a polymerisation initiator and a polymerisation accelerator at ambient temperature and pressure for a period ranging between 2 to 24 hours to obtain a polymer and then linking an inhibitor to pendant carboxyl groups of the spacers in the polymer to obtain an affinity polymer.

Process for the preparation of thermoprecipitating affinity polymers

The present invention provides novel thermoprecipitating polymers of formula 1, processes for the preparation thereof respectively and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, and x and y are integers greater than 1.

The present invention relates to a process for the preparation, of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer comprising a spacer and a co-monomer with a polymerisation initiator and a polymerisation accelerator at ambient temperature and pressure for a period ranging between 2 to 24 hours to obtain a polymer and then linking an inhibitor to pendant carboxyl groups of the spacers in the polymer to obtain an affinity polymer.

The invention relates to a process for the preparation of molecularly imprinted polymers useful for separation of enzymes, which comprises the steps of reacting a complex of enzyme and affinity monomer, a comonomer and a crosslinker, with a polymerization initiator and a polymerization accelerator at ambient temperature and pressure for a period ranging between 2 to 24 hrs, thereby obtaining a crosslinked polymer, crushing the cross linked polymer obtained to fine particles, adding a solvent and extracting imprinted enzyme from the polymer, obtaining the molecularly imprinted polymer, contacting the imprinted polymer with aqueous solution containing imprinted enzyme or a mixture of imprinted enzyme and other enzymes and isolating the enzyme-adsorbed polymer.

Process for the preparation of molecularly imprinted polymers useful for separation of enzymes

The present invention provides a polymer for the controlled release of a pendent chain linked active ingredient, and a process for the preparation of such a polymer for the controlled release of an active ingredient in response to pH. The process involves selecting a vinyl monomer to which the active ingredient molecule is covalently linked through a pendent group, and selecting monomers bearing catalytic groups. The active ingredient-bearing monomer and the catalytic group-containing monomer are brought in juxtaposition either by complexation or molecular imprinting, and then polymerized with a hydrophilic monomer and crosslinker under an inert atmosphere with a suitable polymerization initiator.

Polymer composition for controlled release of active ingredients in

The invention provides a polymer composed of vinyl monomers bearing imidazole, hydroxyl and carboxyl groups arranged in proximity to each other, that exhibits hydrolytic activity similar to serine proteases, and a process for its preparation. The polymer is useful for the hydrolysis of esters and amides to the corresponding alcohols and amines.

Synthetic polymer exhibiting hydrolytic activity, its preparation and

Novel polymer for drag reduction in hydrocarbon fluids is disclosed which comprises polymerising a C-12 to C-18 acrylate or methacrylate monomer and an ionic with or without other monomers acting as fillers or additives at a temperature between 20.degree. and 30.degree. C. with constant stirring and separating the resultant polymer. The preparation of the polymers is simple, shear stability is good even at high shear rates, insensitivity to the presence of any other polar solvent and good solubility in almost all the hydrocarbon liquids. The novel polymer reduces friction in the flow of a hydrocarbon fluid by a factor around 5 at concentrations as low as 1 to 25 ppm.

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Pune, India

Raghunath Anant Mashelkar