Merck Sharp + Dohme Corp.

Institut National De La Recherche Scientifique

Valorbec Societe En Commandite

Rafik Naccache

Roberto Morandotti

Jerry Anthony Murry

Junliang Dong

Luca Razzari

Sophie-Dorothee Clas

Riccardo Piccoli

Fiorenzo Vetrone

Holger Breitenborn

Hongshi Yu

Narayan Vanankaval

A method and a system for determining material-, size-, and morphology-dependent photothermal properties of particles dispersed in solutions, the method comprising using coherently detected pulsed THz radiation, tracking a temperature-dependent refractive index change of the particles dispersion in time and space, and correlating the temperature-dependent refractive index change of the particles dispersion in time and space to temperature values. A system comprises a source of electromagnetic radiation; a THz emitter; a THz detector; and a vessel containing a dispersion of particles, wherein the source of electromagnetic radiation is configured to emit electromagnetic radiation to excite the particles in the dispersion; the THz emitter is configured to send THz radiation to the vessel and the THz detector is configured to receives THz radiation returned by from the vessel.

Method and system for determination of photothermal properties of particles

The present invention is directed to alternative forms of the title phosphodiesterase 4 inhibitor which has the structural formula shown immediately below: 

Alternative forms of the phosphodiesterase-4 inhibitor N-cyclopropyl-1-{3-[(1-oxidopryidin-3-yl)ethynyl]phenyl}-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxyamide

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Laval, Canada

Rafik Naccache