Oregon Health & Science University

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Massachusetts General Hospital Corporation

Rafick-Pierre Sekaly

Genoveffa Franchini

Bruce D Walker

Namal Malimbada Liyanage

Luca Schifanella

Quentin Eichbaum

Monica Vaccari

Elias Haddad

Slim Fourati

Shari Gordon

Mark Cameron

Melvin Doster

Compositions including a therapeutically effective amount of an HIV immunogen in combination with an agent that stimulates the Ras pathway, wherein the agent is not an aluminum salt, are disclosed. Methods are also disclosed for inducing an immune response to HIV, and/or to inhibit or treat HIV infection, in a subject, using an HIV immunogen and an agent that stimulates the Ras pathway. Methods also are disclosed for determining if an immunogenic composition will induce a protective response, and/or to determine if an immunogenic composition is of use to prevent or treat an HIV infection. The methods including determining if the immunogenic composition increases the level of one or more components of the Ras signaling pathway.

Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy

Modulation of PD-1 activity in the presence or absence of an agent as measured by a gene expression profile of at least two genes is provided. Reagents, kits, methods and uses thereof for the modulation of immune function comprise the identification of modulators of PD-1 activity.

Determining whether a test compound modulates PD-1 activity in activated immune cells using gene expression profiles

Growing community of inventors

Port Saint Lucie, FL, United States of America

Rafick-Pierre Sekaly