Lead Discovery Center Gmbh

Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Sotio A.s.

Raffaella Di Lucrezia

Peter Nussbaumer

Tim Bergbrede

Uwe Koch

Axel Choidas

Bert Klebl

Maria Falkenberg-Gustafsson

Claes M Gustafsson

Nils-Göran Larsson

Anke Unger

Peter Schröder

The present invention relates to compounds of the general formula (I): (I), wherein V, W, M, R, R and Y have the designations cited below, or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof, and to processes for the preparation of compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof. The invention also relates to compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof for use as a medicament. Further, the invention relates to compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof for use in the treatment of cancer. Moreover, the invention relates to compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof for treating cancer in simultaneous, alternating or subsequent combination with another cancer therapy.

Quinoline derivatives, processes for their preparation and uses thereof for the treatment of cancer

The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

4-phenyl-coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

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Wuppertal, Germany

Raffaella Di Lucrezia