Carlo Erba S.p.a.

Other

Raffaele Tommasini

Piero Melloni

Alessandro Rossi

Francesco Lauria

Arturo Della Torre

Norina Passerini

Willy Logemann

Vittorio Ambrogi

Nicola Mongelli

PierNicola Giraldi

Ada Buttinoni

Marc'Antonio Parenti

Marc Antonio Parenti

Giuliano Nannini

Giovanni Biasoli

Cyclic derivatives of 1,4-benzoxazine and 1,4-benzothiazine are disclosd, such as, for instance, 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-imidazo[5,1-c][1,4]benzoxazin-1-o ne and 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-8-chloro-imidazo[5,1-c][1,4]benzo xazin-1-one. These compounds are active on the central nervous system, and function as antidepressant agents.

Imidazo[5,1-c][1,4]benzoxazin-1-one

Novel N-tricyclic derivatives of azetidine are disclosed of the general formula ##STR1## where A is a C.sub.1 -C.sub.3 alkylene group, a C.sub.2 -C.sub.3 alkenylene group or a cyclopropylene group, the remaining substituents being defined in the specification. Such compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities. The compound 1-[5-(10, 11-dihydro-5H-dibenzo [a,d]cyclopheptenyl)]-3-methyl-amino-azetidine is illustrative.

N-tricyclic derivatives of azetidine and process for their preparation

Isoindoline derivatives are disclosed, as for instance of the formula: ##STR1## and methods of preparation of these compounds, such as the reaction of o-cyano-benzylbromide with a compound of formula ##STR2## and subsequent saponification. The compounds possess analgesic and anti-inflammatory activity.

Isoindoline derivatives for treating pain

Novel N-tricyclic derivatives of azetidine of the formula: ##STR1## wherein A is a --CH.sub.2 --O-- or an --O--CH.sub.2 group, and the remaining substituents being defined in the specification are disclosed. An illustrative compound is 1-[11-(6,11-dihydro-dibenzo [b,e] oxepinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.

N-tricyclic derivatives of azetidine

Novel N-tricyclic derivatives of azetidine are disclosed of the general formula: ##STR1## WHERE A is a --CH.sub.2 --S-- or --S--CH.sub.2 -- group, the remaining substituents being defined in the specification. Illustrative is the compound 1-[11-(6,11-dihydro-dibenzo [b,e] thiopinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.

N-tricyclic derivatives of azetidine and pharmaceutical compositions and

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are hydrogen, C.sub.1-6 alkyl or alkoxy, at least one of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, R.sup.4 is carboxy, carbalkoxy or a carboxamide group, or a pharmaceutically acceptable salt when R.sup.4 is carboxy are disclosed.

Pyrazine 4-oxide derivatives and process for their preparation

Compounds of the formula (I) ##STR1## are disclosed, wherein at least one of R.sup.1, R.sup.2 and R.sup.3 is C.sub.1.sub.-6 alkyl and the others are hydrogen atoms; R.sup.4 is hydroxy or C.sub.1.sub.-6 alkoxy, or a salt of the compound wherein R.sup.4 is hydroxy with a pharmaceutically acceptable base. A typical compound is, for example, 2-carboxy-5-methylpyrazine 4-oxide.

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Milan, Italy

Raffaele Tommasini