Dpx Holdings B.v.

Patheon Holdings I B.v.

Rafael Wilhelmus Elisabeth Ghislain Reintjens

Mehul Thathagar

Peter Poechlauer

Hubertus Johannes Adrianus Dielemans

Jeroen Hubertina Gerardus Konings

Michel Goldbach

The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.

Preparation of Grignard reagents using a fluidized bed

A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.

Continuous production and reaction of a diazo compound

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Echt, Netherlands

Rafael Wilhelmus Elisabeth Ghislain Reintjens