E.i. Dupont De Nemours and Company

Fmc Corporation

Bristol-Myers Squibb Compnay

Dsm N.v.

Invista North America S.a.r.l.

Corteva Agriscience LLC

E. I. Du Pont Nemours and Co.

Invista Technologies S.a.r.l.

Gary David Annis

Stephen Frederick Mccann

Rafael Shapiro

Thomas Martin Stevenson

Wilson Tam

Christian Peter Lenges

Matthew Richard Oberholzer

Stephen Frederick McCann

Robert J Pasteris

Albert Loren Casalnuovo

Sigridur Soley Kristjansdottir

Yuzhong Chen

Jun Yan

Erin Demko

Weiming Qiu

Helen S M Lu

Bang-Chi Chen

Donald J Dumas

Mary Ann Hanagan

James Michael Garner

William Thomas Zimmerman

Boguslaw Mudryk

Antonius J Teunissen

Nicolas Cuniere

William J Marshall

Charles R Harrison

Christian Hoffmann

Joerg Bruening

Carina S Snijder

Carolina B Hansen

Huiping Zhang

Renee Marie Lett

Eric Deguyon Taylor

Richard Alan Berger

Lucius Rossano

Richard F Davis

Ty Wagerle

Eric DeGuyon Taylor

Eric De Guyon Taylor

Eric G Taylor

Eric De Taylor

Robert James Pasteris

Richard Frank Davis

Helen SM Lu

Alan M Allgeier

The present invention provides a method for preparing a compound of Formula C, Formula D, or Formula F: wherein each R, R, and Ris independently H, SFs, N(C-Calkyl)(C-Calkyl), C(═S)N(C-Calkyl)(C-Calkyl), SON(C-Calkyl)(C-Calkyl), OSO(C-Calkyl), OSON(C-Calkyl)(C-Calkyl), N(C-Calkyl)SO(C-Calkyl), or C-Calkyl, C-Chaloalkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl, C-Chalocycloalkyl, C-Calkylcycloalkyl, C-Ccycloalkylalkyl, C-Ccycloalkylcycloalkyl, C-Calkylcycloalkylalkyl, C-Ccycloalkenyl, C-Calkoxy, C-Chaloalkoxy, C-Ccycloalkoxy, C-Chalocycloalkoxy, C-Ccycloalkylalkoxy, C-Calkenyloxy, C-Calkynyloxy, C-Calkylthio, C-Calkylsulfinyl, C-Calkylsulfonyl, C-Ccycloalkylthio, C-Ccycloalkylsulfinyl, C-Ccycloalkylsulfonyl, C-Ccycloalkylalkylthio, C-Ccycloalkylalkylsulfinyl, C-Ccycloalkylalkylsulfonyl, C-Calkenylthio, C-Calkenylsulfinyl, C-Calkenylsulfonyl, C-Calkynylthio, C-Calkynylsulfinyl, C-Calkynylsulfonyl, or phenyl; or two of R, R, and Ron adjacent ring atoms may be taken together to form a 5-to 7-membered carbocyclic or heterocyclic ring, each ring containing ring members selected from carbon atoms and up to 3 heteroatoms independently selected from up to 2 O, up to 2 S, and up to 3 N, wherein up to 2 carbon atom ring members are independently selected from C(═O) and C(═S) and such ring is optionally substituted with up to 3 substituents independently selected from the group consisting of C-Calkyl, C-Chaloalkyl, C-Calkenyl, C-Chaloalkenyl, C-Calkynyl, C-Chaloalkynyl, C-Ccycloalkyl, C-Chalocycloalkyl, C-Calkylcycloalkyl, C-Chaloalkylcycloalkyl, C-Ccycloalkylalkyl, C-Chalocycloalkylalkyl, C-Calkoxy, C-Chaloalkoxy, C-Calkoxycarbonyl, C-Chaloalkoxycarbonyl, C-Calkylcarbonyl and C-Chaloalkylcarbonyl; and M is an inorganic cation or organic cation.

Process and intermediates for the preparation of certain nematicidal sulfonamides

This application is directed to a compound of Formula II Also disclosed is a process for preparing a compound of Formula II comprising using the compounds of Formulae IV and V Also disclosed is a method for preparing a compound of Formula I comprising contacting a compound of Formula II with a compound of a compound of Formula VI wherein A, AA, R, R, R, R, R, B, Band B, are as defined in the disclosure. 

Pyrrolidinones and a process to prepare them

The present invention provides a method for preparing a compound of Formula C, Formula D, or Formula F: 

Disclosed are compounds of Formulae 1, 1A, 1B and 1C including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

Fungicidal azocyclic amides

A method for preparing a compound of Formula 1 comprising contacting a compound of Formulae 2 and 3 in the presence of a palladium source, a ligand, a base and carbon monoxide wherein R, R, X and Rare as defined in the disclosure. A method for preparing a compound of Formula 5 wherein R, R, R, R, R, Rand Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing a compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method above. 

Method for preparing 2-aminobenzamide derivatives

Disclosed are compounds of Formulae 1, 1A, 1B and 1C including all geometric and stereoisomers, N-oxides, and salts thereof, wherein

Disclosed are solid forms of 8-chloro-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxamide (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed. Disclosed are nematocidal compositions comprising a nematocidally effective amount of a solid form of Compound 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid carriers. Compositions comprising a mixture of a solid form of Compound 1 and at least one other nematicide, insecticide and/or fungicide are also disclosed. Also disclosed are methods for protecting a plant from nematodes comprising applying to the plant, or portion, or seed thereof, or to the growing medium of the plant, a nematocidally effective amount of Compound 1 comprising the polymorph Form A.

Solid forms of nematocidal sulfonamides

Disclosed are solid forms of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed. Disclosed are fungicidal compositions comprising a fungicidally effective amount of a solid form of Compound 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid carriers. Compositions comprising a mixture of a solid form of Compound 1 and at least one other fungicide or insecticide are also disclosed. Also disclosed are methods for controlling plant diseases caused by fungal plant pathogens comprising applying to a plant or portion thereof, or to a plant seed, a fungicidally effective amount of a solid form of Compound 1.

Solid forms of an azocyclic amide

A new method for the preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid compound of Formula 1 is disclosed wherein Ris H or an optionally substituted carbon moiety.

Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids

Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R&#x2014;NHin the presence of a carboxylic acid and a method for preparing a compound of Formula 2 by contacting a compound of Formula 4 with phosphorus tribromide. wherein Ris H, C-Calkyl, cyclopropyl, cyclopropylmethyl or methylcyclopropyl; Ris CHor Cl; Ris C-Calkyl or C-Calkenyl, each optionally substituted with up to 3 halogen and up to 1 phenyl; and X is Cl or Br. Also disclosed is a method for preparing a compound of Formula 5 wherein R, R, Rand Z are as defined in the disclosure,using a compound of Formula 1 that is characterized by preparing the compound of Formula 1 by the method above.

Process for making 3-substituted 2-amino-5-halobenzamides

Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein Ris NHRor OR; Ris CHor Cl; Ris H, C-Calkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; Ris H or C-Calkyl; Y is Br or Cl; X is NRor O; n is 0 or 1; and R, R, R, R, R, R, R, Rand Rare as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula 2 wherein Y is Br and Ris NHRcomprising introducing a gas containing bromine into a liquid containing a compound of Formula 4, and further disclosed is a method for preparing a compound of Formula 5 wherein R, R, Rand Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above. 

Process for preparing 2-amino-5-cyanobenzoic acid derivatives

A method is disclosed for preparing compounds of Formula 1 by combining compounds of Formulae 2 and 3 and a sulfonyl chloride. Also disclosed are compounds of Formula 3, which are useful as starting materials for this method.

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A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.

Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones

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Wilmington, DE, United States of America

Rafael Shapiro