Adhezion Biomedical, LLC

Rafael Ruiz, Sr

Sheng Zhang

Martin Krauss

Amanda Guido

Melissa Brent Hill

Max S Azevedo

Jeoung Soo Lee

Kelsey Moylan

Charles Kenneth Webb

Shannon Phelps

Robert Zimmerman

Nastassia Price

Jeoungsoo Lee

A package system suitable for sterilizing cyanoacrylate compositions and providing the sterile cyanoacrylate compositions a shelf life of at least 24 months, wherein the package system comprises: an ampoule comprising a chamber comprising a cyanoacrylate monomer, wherein the chamber is defined by an opening and sidewalls, wherein the ampoule comprises a material comprising a cyclic olefin copolymer; a multilayer foil seal sealing the opening of the ampoule; and a secondary package housing the ampoule.

Packaging for adhesive compositions

An applicator for storing, sterilizing, and dispensing adhesives. The applicator includes a rigid tapered tip, a body, and a container holding a polymerizable cyanoacrylate monomer adhesive. The applicator is sterilized by radiation and, following sterilization, the adhesive remains substantially unpolymerized for about twenty-four months.

Device and liquid compositions for securing catheters having a rigid tapered tip

Dispensing applicator

A fast-bonding and long-lasting adhesive composition with a high viscosity for attaching eyelash/hair extension systems to human eyelash/hair, comprising: a cyanoacrylate monomer having a straight alkyl chain length of from 4 to 16 carbon atoms; an organic polymer thickening agent; an inorganic thickening agent; and a bonding accelerator, wherein the inorganic thickening agent does not separate from the composition.

Fast bonding hair/eyelash extension adhesive compositions based on medical grade high viscosity cyanoacrylates

Applicator

Applicators for storing, sterilizing, and dispensing adhesives. The applicators comprise a porous tip, a body, and a container containing a polymerizable cyanoacrylate monomer adhesive. The applicators are sterilized by radiation, and following sterilization, the adhesive remains substantially unpolymerized for about twenty four months.

Applicators for storing, sterilizing, and dispensing an adhesive

A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.

Cyanoacrylate tissue adhesives

Liquid dispenser

Sterilized wound healing compositions comprise stabilized cyanoacrylate monomers homogenously mixed together with a naphthoquinone 2,3-oxide, including vitamin K oxides. The compositions are sterilized by irradiation, and the sterilized compositions are shelf stable such that their viscosity does not substantially increase following at least two years of shelf storage. The compositions may be used for closure of open wounds, and the compositions enhance the rate of wound healing relative to wounds not closed with the compositions.

Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides

Liquid dispenser with an elliptical tip

A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.

Wound healing compositions including cyanoacrylate monomers and phenytoin

Liquid dispenser having a tapered tip

Dispensing applicator having a curved elongated nozzle

Liquid dispenser with an extended tip

Growing community of inventors

Hudson, NC, United States of America

Rafael Ruiz, Sr