University of Virginia Patent Foundation

Rafael Rubio

Luiz Belardinelli

Robert M Berne

Jorge Suarez

Eduardo Balcells

Covalent conjugates of water soluble dextrans and adenosine agonists or antagonists wherein the dextran is coupled through the C6 or C8 positions of the purine ring. These compounds activate or block adenosine A.sub.1 or A.sub.2 receptors are useful in treating hypertension.

Adenosine dextran conjugates

A method of diagnosing and treating arrhythmias caused by re-entry in the A-V node by administering to a human or animal an effective amount of adenosine that restores normal sinus rhythm.

Adenosine in the treatment of supraventricular tachycardia

A method of relieving atrioventricular conduction block by administering to a human or animal an effective amount of an adenosine antagonist that competitively inhibits adenosine or that reduces the level of adenosine present in myocardial tissue and associated fluids. A method of diagnosing atrioventricular conduction block caused by ischemia of the heart by measuring the time delay between atrial and ventricular excitation before and after the administration of an adenosine antagonist. Specific antagonists disclosed include methylxanthines.

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Charlottesville, VA, United States of America

Rafael Rubio