Midatech Limited

Laboratorios Farmacéutios Rovi, S.a.

Rafael Ojeda Martinez De Castilla

Thomas William Rademacher

Soledad Penades Ullate

Gottfried Himmler

Ralf Kircheis

Ivan Lopez-Belmonte Encina

G C Mudde

Manuel Martin Lomas

Jose Luis De Paz Carrera

Africa Garcia Barrientes

Godfrey Bradman

Geert C Mudde

T Midatech Limited Rademacher

Nanoparticles comprising adjuvants and antigens, such as tumor and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.

Nanoparticles comprising antigens and adjuvants, and immunogenic structures

Materials and Methods are disclosed for producing nanoparticles linked to antibacterial ligands, including antibiotics and/or molecules which bind to bacterial markers, and for the use of the nanoparticles for the treatment of conditions treatable by the antibiotic ligands.

Nanoparticles comprising antibacterial ligands

Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through this procedure a drastic reduction is achieved in the total synthesis time in comparison with the process traditionally employed, together with increased reproducibility thereof, permitting the standardization thereof.

Process for the synthesis of unprotected pentasaccharides from a protected pentasaccharide precursor

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Madrid, Spain

Rafael Ojeda Martinez De Castilla