Cellphire, Inc.

Flamel Ireland Limited

Rafael Jorda

Keith Andrew Moskowitz

Amber Nicole Lee

Braden Carl Ishler

Stephen Edward Amos

Michael Alexander Mathews

Glen Michael Fitzpatrick

Joshua Donald Montgomery

Narendra Nath Tandon

William Matthew Dickerson

You-Ping Chan

Olivier Breyne

Rémi Meyrueix

Gauthier Pouliquen

Daniel Allen Sheik

Ying Yi Zheng

Provided herein are RNA agent-loaded platelets, methods of preparing RNA agent-loaded platelets, and methods of using RNA agent-loaded platelets. In some embodiments, methods of loading RNA agents into platelets include treating platelets with a RNA agent, a cationic transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Platelets as delivery agents

Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Platelet derivative compositions, and pluralities of containers containing same

Methods using freeze-dried platelet derivative compositions for restoring hemostasis in a subject

In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.

Platelets loaded with anti-cancer agents

Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Materials and methods for producing blood products

The present invention relates to a composition comprising at least one active ingredient with low aqueous solubility, said active ingredient being present therein in a form noncovalently associated with nanoparticles formed by at least one POM polymer of formula (I), and in which said active ingredient is present in a proportion of at least 5 &#x3bc;mol/g of POM. It is also directed towards the use of such nanoparticles, noncovalently associated with an active ingredient, with a view to increasing the aqueous solubilization of said active ingredient.

Composition comprising an active agent with low aqueous solubility

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Merignac, France

Rafael Jorda