Sandoz Ag

Novartis Ag

Biochemie S.a.

Rafael Garcia

Johannes Ludescher

José Diago

Victor Centellas

Albert Codony

Jordi Rifa

Jos&eacute; Diago

Immaculada Bosch

Oriol Martorell

Marta Poch

The present invention concerns a process for the preparation of the compound of formula  The compound of formula (1) is the key intermediate in the synthesis of some antibacterial agents of the triamilide class, such as Tulathromycin, useful to treat bacterial and protozoa infections.

Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4&#x2033; of the cladinose ring by an epoxide group

The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.

Derivatives of azithromycin

The present invention relates to new processes for the preparation of gabapentin by the desilylation of a silylated gabapentin or by the silylation-desilylation of an acid addition salt of gabapentin with a silylating agent.

Processes for the preparation of gabapentin

Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.

Macrolide solvates

Azithromycin in the form of a stable monohydrate and processes for the preparation of azithromycin in the form of an, e.g. stable, monohydrate.

Growing community of inventors

Barcelona, Spain

Rafael Garcia