Eli Lilly and Company

Ligand Pharmaceuticals, Inc.

Rafael Ferritto Crespo

Alan M Warshawsky

Jose Alfredo Martin

Maria Dolores Martin-Ortega Finger

Robert J Ardecky

Yanping Xu

Quanrong Shen

Dawn Alisa Brooks

Carlos Lamas-Peteira

Lourdes Prieto

Isabel Rojo Garcia

Isabel Rojo

Maria Martin-Ortega Finger

Chahrzad Montrose-Rafezadeh

Anne-Reifel Miller

Maria Rosario Gonzales Garcia

Alicia Torrado

The present invention is directed to a novel compound, its composition and use of a compound having a structural formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomers thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases 

Selective peroxisome proliferator activated receptor modulators

The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I) 

Amide linker peroxisome proliferator activated receptor modulators

Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, &#x2014;CH&#x2014; or &#x2014;CHCH&#x2014;; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to Rand W, Ris (CH)&#x2014;CH(OR)&#x2014;(CH)E, &#x2014;(CH)&#x2550;C(OR)&#x2014;(CH)E, &#x2014;(CH)&#x2014;CH(Y)&#x2014;(CH)E or (CH)&#x2550;C(Y)&#x2014;(CH)E; wherein E is COOR, C&#x2013;Calkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C&#x2013;Calkyl, haloalkyl and aryl-C-4-alkyl; Ris H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, &#x2014;COR, &#x2014;COOR, &#x2014;CONRR, &#x2014;C(S)R, &#x2014;C(S)ORor C(S)NRR, Ris H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O&#x2014;, CH&#x2014;, &#x2014;CHCH&#x2014; or CH&#x2550;CH&#x2014; and is bonded to a carbon atom in Phenyl Ring A that is ortho to R. R&#x2013;Rare independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2 

Modulators of peroxisome proliferator activated receptors

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Madrid, Spain

Rafael Ferritto Crespo