Boston Scientific Neuromodulation Corporation

Cardiac Pacemakers, Inc.

Advanced Bionics Corporation

Other

Lowe Graham Jones Pllc

Boston Scientific Neuromodulation Corporaton

Rafael Carbunaru

Todd K Whitehurst

Kristen N Jaax

Jordi Parramon

Andrew DiGiore

Brett Daniel Schleicher

Michael A Moffitt

Kerry A Bradley

Goran Nils Marnfeldt

Matthew Isaac Haller

Courtney C Lane

James P McGivern

Tom Xiaohai He

Robert Dai Ozawa

James Carl Makous

Greg Baldwin

Kelly Hobart McClure

Que T Doan

Matthew Lee McDonald

Joey Y Chen

Jess Weiqian Shi

Md Mizanur Rahman

Matt Isaac Haller

David K L Peterson

Janusz A Kuzma

Rosana Esteller

Jason J Hamann

Ross Daniel Venook

Kiran K Gururaj

Allison M Foster

Kirsten N Jaax

Roger Noel Hastings

David J Ternes

Anne Margaret Pianca

John Michael Barker

John Matthew Swoyer

Dongchul Lee

Sridhar Kothandaraman

Stephen B Ruble

Bradley Lawrence Hershey

Matthew Braden Flowers

Jesse D Geroy

Gaurav Gupta

Salomo Siilas Murtonen

Ellis Garai

Christopher Ewan Gillespie

Meredith Lee Anderson

Jeff Gagnon

Jacob Matthew Muhleman

Terry Ferrell

Kenneth A McGiboney

Changfang Zhu

Joseph M Bocek

Jeffery Van Funderburk

Carla Mann Woods

Alfred E Mann

Tianhe Zhang

Stephen Carcieri

Gary Thomas Seim

Hemant Bokil

Scott R Vanderlinde

Dennis Zottola

Mun Pook Lui

Janusz Kuzma

David Ernest Wechter

Jay Daulton

Dennis Allen Vansickle

Les Norman Peterson

Mark Pierre

Adam Thomas Featherstone

Sarvani Grandhe

George Vamos

Jessica Block

Mizanur Rahman

Gregory Baldwin

Justin Holley

Adarsh Jayakumar

Thien Tich Doan

Peter K Johnson

Nazim Wahab

Soroush Massoumi

Derrick Sung

Chirag M Patel

Jim Makous

Cliff Brainard

Charles Tilden Hagan, Iv

Archie Eslabon Huerto

Salomo Murtonen

Jordi Parramo

Matt Flowers

Andrew Digiore

An example of a system for delivering neurostimulation to a patient and controlling the delivery of neurostimulation using sensors may include a stimulation output circuit, a sensing circuit, and a control circuit. The stimulation output circuit may be configured to deliver the neurostimulation. The sensing circuit may be configured to receive sensed signals from the sensors and to process the sensed signals. The sensing circuit has adjustable settings controlling the processing of the sensed signals. The control circuit may be configured to control the delivery of the neurostimulation using the processed sensed signals and to control the settings of the sensing circuit according to a sequence of sensing blocks each including a set of sensing parameters.

Method and apparatus for sequencing sensing blocks for neuromodulation

An example of a neurostimulation system may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to program a stimulation device for delivering the neurostimulation according to a stimulation program specifying a present stimulation field set including stimulation field(s) each defined by a set of active electrodes selected from a plurality of electrodes. The stimulation control circuit may be configured to determine the stimulation program and may include field programming circuitry that may be configured to set the present stimulation field set to an initial stimulation field set specifying stimulation fields allowing for the delivery of the neurostimulation to produce an intended effect and to identify an optimal stimulation field set that satisfies one or more optimization criteria by removing stimulation field(s) from the initial stimulation field set.

Method and apparatus for subtraction-based programming of neurostimulation fields

Systems and methods for selectable lateral spinal cord stimulation are discussed. An exemplary neuromodulation system includes a programming device and an electrostimulator. The programming device can receive information about placement of at least one lead in a vicinity of a lateral portion of a spinal cord, identify one or more lateral spinal neural targets based on the information about placement of the at least one lead, and receive a user selection from selectable stimulation modes for stimulating the identified one or more lateral spinal neural targets. The electrostimulator can apply electrostimulation energy to the identified one or more lateral spinal neural targets via the at least one lead in accordance with the user selection from the selectable stimulation modes.

Systems and methods for selectable lateral spinal cord stimulation

Waveforms for a stimulator device, and methods and circuitry for generating them, are disclosed having high- and low-frequency aspects. The waveforms comprise a sequence of pulses issued at a low frequency which each pulse comprising first and second charge-balanced phases. One or both of the phases comprises a plurality a monophasic sub-phase pulses issued at a high frequency in which the sub-phase pulses are separated by gaps. The current during the gaps in a phase can be zero, or can comprise a non-zero current of the same polarity as the sub-phase pulses issued during that phase. The disclosed waveforms provide benefits of high frequency stimulation such as the promotion of paresthesia free, sub-threshold stimulation, but without drawbacks inherent in using high-frequency biphasic pulses.

Stimulation waveforms with high- and low-frequency aspects in an implantable stimulator device

Medical device systems and methods for providing spinal cord stimulation (SCS) are disclosed. The SCS systems and methods provide therapy below the perception threshold of the patient. The methods and systems are configured to measure neurological responses to stimulation and use the neurological responses as biomarkers to maintain and adjust therapy. An example of neurological responses includes an evoked compound action potential (ECAP).

Automatic adjustment of sub-perception therapy in an implantable stimulator using detected compound action potentials

A method of treating an ailment suffered by a patient using one or more electrodes adjacent spinal column tissue of the patient, comprises delivering electrical modulation energy from the one or more electrodes to the spinal column tissue in accordance with a continuous bi-phasic waveform having a positive phase and a negative phase, thereby modulating the spinal column tissue to treat the ailment. An implantable electrical modulation system, comprises one or more electrical terminals configured for being coupled to one or more modulation leads, output modulation circuitry capable of outputting electrical modulation energy to the electrical terminal(s) in accordance with a continuous bi-phasic waveform, and control circuitry configured for modifying a shape of the continuous bi-phasic waveform, thereby changing the characteristics of the electrical modulation energy outputted to the electrode(s).

System and method for shaped phased current delivery

An external control device, neuromodulation system, and method of providing therapy to a patient using an implantable neuromodulator implanted within the patient. Electrical modulation energy is delivered from the neuromodulator to the patient in accordance with the pre-existing modulation program when in one of the super-threshold delivery mode and the sub-threshold delivery mode. Operation of the neuromodulator is switched to the other of the super-threshold delivery mode and the sub-threshold delivery mode. A new modulation program may be derived from a pre-existing modulation program, and the neuromodulator may deliver the electrical modulation energy to the patient in accordance with the pre-existing modulation program during the other of the super-threshold delivery mode and the sub-threshold delivery mode.

Neuromodulation system and method for transitioning between programming modes

An algorithm programmed into the control circuitry of a rechargeable-battery Implantable Medical Device (IMD) is disclosed that can adjust the charging current (Ibat) provided to the rechargeable battery over time (e.g., the life of the IMD) in accordance with one or more of the parameters having an effect on rechargeable battery capacity, such as number of charging cycles, charging current, discharge depth, load current, and battery calendar age. The algorithm consults such parameters as stored over the history of the operation of the IMD in a parameter log, and in conjunction with a battery capacity database reflective of the effect of these parameters on battery capacity, estimates a change in the capacity of the battery, and adjust the charging current in one or both of trickle and active charging paths to slow the loss of battery capacity and extend the life of the IMD.

Circuitry for charging a battery in an implantable medical device in accordance with historical parameters impacting battery capacity

Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.

Controlling charge flow in the electrical stimulation of tissue

An algorithm programmed into the control circuitry of a rechargeable-battery Implantable Medical Device (IMD) is disclosed that can quantitatively forecast and determine the timing of an early replacement indicator (tEOLi) and an IMD End of Life (tEOL). These forecasts and determinations of tEOLi and tEOL occur in accordance with one or more parameters having an effect on rechargeable battery capacity, such as number of charging cycles, charging current, discharge depth, load current, and battery calendar age. The algorithm consults such parameters as stored over the history of the operation of the IMD in a parameter log, and in conjunction with a battery capacity database reflective of the effect of these parameters on battery capacity, determines and forecasts tEOLi and tEOL. Such forecasted or determined values may also be used by a shutdown algorithm to suspend therapeutic operation of the IMD.

Determining and forecasting end of life for an implantable medical device having a rechargeable battery

Multi-phasic fields are produced at a neuromodulation site using electrodes. A first phase is directed at a target region such that a first-polarity electrical charge is injected to the target region, and a second phase is directed at portions of the neuromodulation site other than the target region, such that a second-polarity electrical charge opposite the first-polarity electrical charge is injected to those portions of the neuromodulation site to essentially neutralize the first-polarity charge injected at the neuromodulation site while maintaining at least a portion of the first-polarity charge at the target region. In some embodiments, each anode used to produce the first phase is used as a cathode to produce the second phase, and each cathode used to produce the first phase is used as an anode to produce the second phase, and the quantity of charge injected by each electrode in both phases is essentially zero.

Locally-polarized and globally unpolarized neuromodulation system and method

A method and external control device for providing therapy to a patient using first and second electrodes implanted within the patient is provided. A train of electrical multi-phasic pulses is generated. A first electrical current is sourced from the second electrode and at least a portion of the first electrical current is sunk to the first electrode during a stimulation phase of each multi-phasic pulse, thereby therapeutically stimulating a first tissue region adjacent the first electrode. A second electrical current is sourced from the first electrode and at least a portion of the second electrical current is sunk to the second electrode during a charge recovery phase of each multi-phasic pulse, thereby recovering at least a portion of the charge that had been injected into the patient during the stimulation phase of each multi-phasic pulse, and therapeutically stimulating a second tissue region adjacent the second electrode.

Charge recovery bi-phasic control for tissue stimulation

Growing community of inventors

Valley Village, CA, United States of America

Rafael Carbunaru