Gador S.a.

University of Leiden

Quimica Sintetica, S.a.

Gador Sociedad Anonima

Conicet -consejo Nac. De Investigaciones Científicas Y Técnicas

Rafael Alberto Labriola

Dora Graciela Tombari

Adriana Vechhioli

Socrates Papapoulos

Adriana Vecchioli

Emilio Ja Roldan

Constanza Pia Mangone

Maria Beatriz Garcia

Clemens W Lowik

Ermond R Van Beek

Nelida Mondelo

Jose Luis Ferretti

Eduardo Miguel Rustoy

Gerardo Burton

A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.

Crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it

A method to obtain a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.

The solid state chemistry of 17&#x3b2;-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-&#x3b1;-androst-1-en-3-one of which the international nonproprietary name is Dutasteride (the active ingredient in products marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) and its process for preparing. The synthetic process comprises formation of the mixed anhydride, its subsequent reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water.

Solid and crystalline dutasteride and processes for preparation thereof

It comprises reducing the hydroxy ester of formula (X) by reacting it in DMF and then with an iminium salt of formula (XIII) formed in situ with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducing agent to form the ester of formula (XII), which is then reacted with dimethylamine in a polyhydroxylated solvent medium at an appropriate

Process for preparing N,N,6- trimethyl-2-(4-methylphenyl)-imidazo- &lsqb;1,2-a&rsqb;-pyridine- 3-acetamide and salts thereof

Therapeutic use of

Bone mass anabolic composition comprising olpadronate

Growing community of inventors

Buenos Aires, Argentina

Rafael Alberto Labriola