Sol-gel Technologies Ltd.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Mayne Pharma LLC

Hikari Laboratories Ltd.

Raed Abu-Reziq

Ofer Toledano

Hanan Sertchook

Leora Shapiro

Haim Bar-Simantov

Natalia Loboda

Amani Zoabi

Nissim Bilman

David Avnir

Craig A Martin

William T Sommer

Laibin Bruce Yan

Guy Nesher

Gad Marom

Itzik Yosef

Rachael Ben Knaz

Assaf Zeira

Ahmad Zarour

Yafit Schnell

Suheir Omar

Charlie Batarseh

Dmitri Gelman

Srikanth Sriadibhatla

Esti Weiss

Suzana Natour

Craig Arlen Martin

The present invention provides microcapsules encapsulating hydrophilic or hydrophobic active agents in an inorganic shell, processes for their preparation and compositions comprising them.

Microcapsules and processes for their preparation

The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.

Method for preparing particles comprising metal oxide coating and particles with metal oxide coating

Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived mixture comprising NR may be further used without further processing in a variety of products, particularly in a cosmetic product.

Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent

The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.

Microcapsules comprising active ingredients and a metal oxide shell, a method for their preparation and uses thereof

A process for preparing nanocapsules having a core-shell structure, comprising: (a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.

Formation of nanometric core-shell particles having a metal oxide shell

The present invention provides a composite comprising at least one hydrophobic organic compound and a matrix of at least one metal; wherein said at least one hydrophobic compound is entrapped within said matrix, compositions comprising at least one composite and methods of its preparation.

Metal entrapped compounds

The present invention relates to a microcapsule exhibiting desirable sustained-release properties, which microcapsule comprises a core material comprising an active ingredient encapsulated within a silica shell, characterized in that the outer surface of such silica shell has a layer of a metal selected from Group 2a, Group 8, Group 2b or Group 3a of the Periodic Table bound thereto. In other aspects this invention relates to a method of making such a microcapsule; a pesticidal composition comprising microcapsules comprising a pesticidal active ingredient and a suitable carrier; and to a method of controlling pests comprising applying an effective amount of such a pesticidal composition to a locus where pests are or are expected to be present.

Sustained release silica microcapsules

The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.

Compositions for topical application comprising a peroxide and retinoid

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Jatt Hamesholash, Israel

Raed Abu-Reziq