Dynavax Technologies Corporation

Alza Corporation

Radwan Kiwan

Robert L Coffman

Gary S Ott

Stewart D Chipman

Samuel Zalipsky

Holger Kanzler

Melissa A Kachura

Robert J Milley

John A DeMattei

John Demattei

Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.

Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof

The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.

Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof

The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.

Branched chimeric compounds, and methods of use thereof

Linear chimeric compounds and methods of use thereof

Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof

A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.

Releasable linkage and compositions containing same

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Albany, CA, United States of America

Radwan Kiwan