Pliva Farmaceutska

Sour Pliva

Radmila Naumski

Bozidar Suskovic

Zlatko Vajtner

Zdenko Mubrin

Vera Gomercic

N-acyl derivatives of the peptidoglycan monomer of the formula I ##STR1## wherein R stands for an acyl group of a straight-chain C.sub.2-18 alkyl carboxylic acid, or a branched-chain C.sub.5-18 alkyl carboxylic acid, or an unsaturated C.sub.12-18 alkenyl carboxylic acid, or a C.sub.7-12 aromatic carboxylic acid, and pharmaceutically acceptable salts thereof. A process for the preparation thereof and their use in pharmaceuticals, which are particularly indicated as immunomodulators and immunoadjuvants in humans and animals.

N-acyl derivatives of the peptidoglycan monomer, pharmaceutically

A complex of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglotaminyl- (L)-meso-diamino-pimelyl-(D-amide)-D-alanyl-D-alanine with bivalent metals chosen from the group comprising Cu.sup.2+, Zn.sup.2+, Co.sub.hu 2+ ; Ni.sup.2+ and Cd.sup.2+ in the molar ratio of the organic ligand: Cu.sup.2+ =2:1 and the organic ligand: Zn.sup.2+ or Co.sup.2+ or Ni.sup.2+ or Cd.sup.2+ =1:1, compositions containing it and their use in the treatment of immunological insufficiencies and disturbances in humans and animals.

Growing community of inventors

Zagreb, Yugoslavia

Radmila Naumski