University of South Florida

Torrey Pines Institute for Molecular Studies

University of Minnesota

Radleigh G Santos

Richard Allen Houghten

Lindsey Neil Shaw

Marcello Angelo Giulianotti

Renee Marie Fleeman

Clemencia Pinilla

Carrie Haskell-Luevano

Adel Nefzi

Skye Doering

Jon Richard Appel

Marc A Giulianotti

Marcello A Giulianotti

The invention provides compounds having the general formula I: and salts thereof, wherein the variables R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Selective small molecule peptidomimetic melanocortin ligands

Disclosed herein are efflux pump inhibitors and pharmaceutical compositions comprising the same. The efflux pump inhibitors may be used in methods of preventing antibiotic resistance in a subject, and in methods of treating a bacterial infection in a subject. The efflux pump inhibitor may be co-administered with an antibiotic.

Polyamine compounds targeting the efflux pumps of multi-drug resistant bacterial pathogens and methods of using the same

Certain embodiments of the invention provide a compound of formula (I):R&#x2014;C(&#x2550;O)&#x2014;W&#x2014;X&#x2014;Y&#x2014;Z&#x2014;N(R)&#x2003;&#x2003;(I)or a salt thereof, wherein R, R, W, X, Y and Z are as defined herein, as well as methods of use thereof.

Melanocortin ligands and methods of use thereof

The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Bis-cyclic guanidine compound compositions, methods of use and treatment thereof

The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition {e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

BIS-cyclic guanidine compound compositions, methods of use and treatment thereof

Growing community of inventors

Port St. Lucie, FL, United States of America

Radleigh G Santos