Institute of Organic Chemistry and Biochemistry Ascr, V.v.i.

Radim Nencka

Gabriel Birkus

Ondrej Pav

Ivan Rosenberg

Tomas Jandusik

Milan Dejmek

Michal Sala

Petra Brehova

The present disclosure relates to 3'3&#x2032;-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.

3'3&#x2032;-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator

The present disclosure relates to 2'3&#x2032; cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

2'3&#x2032; cyclic dinucleotides with phosphonate bond activating the sting adaptor protein

Provided herein are the 3'3&#x2032; cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

3'3&#x2032; cyclic dinucleotides with phosphonate bond activating the sting adaptor protein

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Radim Nencka