Hybridon, Inc.

Spring Bank Pharmaceuticals, Inc.

F-star Therapeutics, Inc.

Migenix, Inc.

Invox Pharma Limited

Sperovie Biosciences, Inc.

Other

Micrologix Biotech Inc.

Spring Break Pharmaceuticals, Inc.

Spring Bank

Radhakrishnan P Iyer

Sudhir Agrawal

Seetharamaiyer Padmanabhan

Dong Yu

Ivan Habus

Shenghua Zhou

Sreerupa Challa

Weitian Tan

Geeta Meher

Anjaneyulu Sheri

Theresa Devlin

Yi Jin

Rayomand H Gimi

Zhiwei Jiang

Arlene Roland

Wenqiang Zhou

Dillon Cleary

Nan-Hui Ho

Mao-Jun Guo

Weitan Tan

John E Coughlin

Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.

Compounds, compositions, and methods for the treatment of disease

Compounds,compositions, and methods for the treatment of disease

Compounds,Compositions, and methods for the treatment of disease

The invention provides a method of treating a microbial infection in a subject and a method of improving an immune system response in a subject against a disease, condition, infection, or virus thereof, by administering an effective amount of a nucleoside, short oligonucleotide compound or an analog thereof, or a pharmaceutically acceptable salt, racemate, enantiomer, diastereomer, geometric isomer, or tautomer thereof. In addition, the invention provides methods for treating or preventing a viral infection, bacterial infection, parasitic infection, or fungal infection in a subject (such as, a human). The compounds of the invention include, for example, di-, and trinucleotide compounds as provided herein. The compounds of the invention are useful for different therapeutic applications including, such as, prophylactics and therapeutics. The invention also provides design and synthesis of a compound that is useful for various therapeutic applications as mentioned herein.

Short oligonucleotides as vaccine adjuvants and therapeutic agents

The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: 

Compositions and methods for treating viral infections

The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Nucleotide and oligonucleotide prodrugs

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

Oligonucleotide analogs as therapeutic agents

Growing community of inventors

Shrewsbury, MA, United States of America

Radhakrishnan P Iyer