Idenix Pharmaceuticals, Inc.

Merck Sharp + Dohme Corp.

Pierre Fabre Medicament

Rachid Rahali

Gilles J Gosselin

Cyril B Dousson

Izzat Tiedje Raheem

David Dukhan

Francois-Rene Alexandre

Christophe Parsy

Stéphane Poigny

Jean-Laurent Paparin

El Bachir Kaloun

Houcine Rahali

Gilles Gosselin

Guillaume Brandt

Karim Bedjeguelal

Rémi Rabot

Serge Grisoni

Hugues Bienayme

Aurélien Salanson

Antoine Dumoulin

Bachir Kaloun El

Eric Tam

Pascaline Klein

François-René Alexandre

Christophe Claude Parsy

Hugues Bienhayme

The present invention is directed carbocyclic nucleoside reverse transcriptase inhibitors compounds of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.

Carbocyclic nucleoside reverse transcriptase inhibitors

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3'-substituted methyl or alkynyl nucleosides of Formula I: (I); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, PD, R, R, R, Rand Z are as defined herein. 

3'-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV

The present invention relates to inhibitors of protein kinases of formula I: which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.

Pyrroloquinoline derivatives and their use as protein kinases inhibitors

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Saint Laurent des Arbres, France

Rachid Rahali