Angelini Pharma, Inc.

Paladin Labs Inc.

Labopharm Inc.

Paladin Labs (barbados) Inc.

Paladin Labs Europe Limited

Labopharm Europe Limited

Labopharm (barbados) Limited

Angelini Labopharm, LLC

Rachid Ouzerourou

Damon Smith

Sonia Gervais

Pauline Contamin

My Linh Ma

Miloud Rahmouni

Angela Ferrada

Fouzia Soulhi

Vincent Lenaerts

Johnatan Bacon

Patricia Laure Ouadji-Njiki

Jonathan Bacon

Sybil Roberston

Louise Fortier

Milloud Rahmouni

The invention relates to a once a day formulation of trazodone or a trazodone derivative. The formulation contains trazodone or a trazodone derivative and a controlled release excipient so that, once administered orally, the trazodone or the trazodone derivative is maintained at a therapeutic plasma concentration from at least 1 hour to at least 24 hours after initial administration. After administration, the initial therapeutic action takes effect within the first hour and lasts at least about 24 hours. This therapeutic effect remains relatively and substantially stable for the remaining period of 24 hours. The formulations can be used for treating depression and/or sleeping disorders.

Trazodone composition for once a day administration

The invention relates to a sustained release formulation for delivering one or more pharmaceutically active agents. The formulation comprises cross-linked high amylose starch and at least one pharmaceutically active agent, and optionally can be subdivided into smaller dosage forms where the smaller dosage forms have substantially the same sustained release properties as the formulation from which they were derived. The formulations can provide sustained release for up to at least 24 hours, and because of their divisability permits a recipient of the active agent or the person administering the active agent to titrate the dosage of the agent.

Sustained drug release composition

Sustained drug release compositions

A solid dosage formulation having a core with a pharmacological agent dispersed in a first controlled-release matrix from which release of the agent is relatively slow; and a coat formed over the core and having the agent dispersed in a second controlled-release matrix from which release of the agent is relatively fast. The first matrix can be a cross-linked high amylose starch and the second matrix can be a mixture of polyvinyl acetate and polyvinylpyrrolidone.

Controlled-release compositions

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Anjou, Canada

Rachid Ouzerourou