Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Nice Sophia Antipolis

Université Cote D'azur

Centre National De La Recherche Scientifique-cnrs

Ocp Sa

Chu De Nice

Centre Hospitalier Universitaire De Nice

Université Mohammed Vi Polytechnique

Inserm

Rachid Benhida

Stephane Rocchi

Robert Ballotti

Cyril Ronco

Thierry Passeron

Anthony Martin

Patrick Auberger

Guillaume Robert

Oleksandr Grytsai

Pascal Dao

Gian Marco De Donatis

Rachid Boulif

Nedra Tekaya

Emile Jaune

Alexandre Puissant

Vincent Malnuit

Jean-Patrick Joly

Maria Duca

Michael Cerezo

Khaoula Khaless

Antoine Millet

Magali Plaisant

Mohsine Driowya

Stéphane Rocchi

De Donatis Gian Marco

The present invention relates to a compound of general formula (I), wherein Ris OCHCHOCHor OCH, R'is H or OH, Ris Cl, F, Br or I, with the proviso that when: Ris OCHCHOCHthen R′is H, Ris OCHthen R′is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.

Substituted halo-quinoline derivatives, method of preparation and applications thereof

The present disclosure relates to biguanide derivatives of formula (I) and their rearrangement products. The present disclosure also relates to the use of these compounds in a method for treating cancer, in particular melanoma. 

Biguanide derivatives and their rearrangement products for use in the treatment of cancer

The present invention relates to compound of general formula (I) Ris selected from H, aryl and alkyl, Ris selected from H, alkyl, aryl and CO&#x2014;R; Ris selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR, NRR, ORand SR; Ris selected from (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl and (C-C) aryl, Rrepresents H, R, aryl, OH, OR, O-aryl, SH, SR, S-aryl, CN, NO, CF, COOR, SONRR, CONRR, NH, NHR, NH-aryl, NRR, NHCORor aminoacyl; Ris alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di(alkyl); Rand Ridentical or different are H or alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. 

Substituted hydrophobic benzene sulfonamide thiazole compounds for use in treating cancer

The present invention relates to compound of general formula (1) wherein Rrepresents C-Caryl comprising one or two fused rings, wherein from 2 to 5 carbon atoms may be replaced with a heteroatom selected from O, S and NR, and eventually substituted with from 5 to 11 substituents selected from R, halo, CN, NO, CF, OCF, COOR, OCOR, SONRR, CONRR, NRR, NRCOR, (CH)&#x2014;NRR, (CH)&#x2014;ORand (CH)SR, as well as, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. 

Benzene sulfonamide thiazole compounds

Acadesine derivatives as a drug, as well as the derivatives for the treatment of cancer and in particular for the treatment of chronic myeloid leukemia are described. Also, product containing the derivatives and at least one second active ingredient as a combination product for simultaneous, separate or sequential administration, in the treatment of cancer, as well as a pharmaceutical composition containing the derivatives and a pharmaceutically acceptable carrier are described. Finally, a method for inhibiting the in vitro cell proliferation including the placement of an in vitro cell in contact with the derivatives and methods for synthesis of said derivatives and methods for synthesis of the derivatives are described.

Acadesine derivatives, products and compositions including same, therapeutic uses thereof, and methods for synthesizing same

Growing community of inventors

Nice, France

Rachid Benhida