Centre National De La Recherche Scientifique

Universitéde Strasbourg

Etat Francais (Ministère Des Armées), Represente Par La Direction Centrale Du Service De Santé Des Armees

Etat Français Représenté Par La Direction Centrale Du Service De Santé Des Armées

Rachid Baati

Jagadeesh Yerri

José Dias

Alain Wagner

Florian Nachon

Laure Dehuyser

Christopher Mueller

Alex Maryan-instone

Richard Brown

Evelyne Schaeffer

Mallikarjuna Reddy Nimmakayala

Camille Voros

Raymond Franck Razafindrainibe

Richard C D Brown

Julien De Sousa

The present invention relates to a compound of formula (I), or one of its pharmaceutically acceptable salts: (I) wherein R1, R2 and —X—Y— have specific definitions. It also relates to the use of such a compound in therapy; and to a process for preparing it.

3,6-disubstituted-2-pyridinaldoxime scaffolds

Disclosed is a compound of formula (II), as well as to a process for preparing the compounds of formula (II) by a chemoselective Sonogashira reaction. It also relates to a pharmaceutical composition including at least one compound of formula (II) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and/or in the treatment of cancer; and/or for use as antiviral drug.

6-Substituted 3-Fluoro-2-Pyridinaldoxime, 3-Fluoro-2-pyridine hydroxamic acid, and 3-Fluoro-2-Pyridinamidoxime scaffolds

The present invention relates to new anti-infectious compounds consisting of (i) a polar head having from one to three mannose, dimannose or trimannose moieties, which is coupled through an appropriate linker to (ii) a single lipid chain of at least 17 carbon atoms in length. Pharmaceutical compositions and therapeutic uses thereof are also provided.

Mannosylated compounds useful for the prevention and the treatment of infectious diseases

Growing community of inventors

Strasbourg, France

Rachid Baati